Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly
expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved …

Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

Bile acids are amphipathic molecules that were previously known to serve as fat solubilizers
in the intestine in postprandial conditions. In the last two decades, bile acids have been …

ABSTRACT Introduction: Farnesoid X receptor (FXR), a nuclear receptor mainly expressed
in enterohepatic tissues, is a master for bile acid, lipid and glucose homeostasis …

The nuclear receptor farnesoid-X-receptor (FXR) plays an essential role in bile acid,
glucose, and lipid homeostasis. In the last two decades, several diseases, such as obesity …

Cholestasis is a common feature of liver injury, which manifests as bile acid excretion and/or
enterohepatic circulation disorders. However, very few effective therapies exist for …

Bile acids are steroid-derived molecules synthesized in the liver, secreted from hepatocytes
into the bile canaliculi, and subsequently stored in the gall bladder. During the feeding, bile …

In recent years, the rapid development of network-based methods for the prediction of drug–
target interactions (DTIs) provides an opportunity for the emergence of a new type of virtual …

The mechanism of transcriptional activation/repression of the nuclear receptors (NRs)
involves two main conformations of the NR protein, namely, the active (agonistic) and …

Farnesoid X receptor (FXR) plays a key role in bile acid homeostasis, inflammation, fibrosis,
lipid and glucose metabolism and is emerging as a promising therapeutic target for …