abstract Interleukin (IL)-4 and IL-13, signature type 2 cytokines, exert their actions by binding
to two types of receptors sharing the IL-4R a chain (IL-4Ra). Since IL-4 and IL-13 play …

Pulmonary functional imaging may be defined as the regional quantification of lung function
by using primarily CT, MRI, and nuclear medicine techniques. The distribution of pulmonary …

Background Patients with eosinophilic asthma often report poor symptomatic control and
quality of life. Anti-IL-5 therapy, including anti-IL-5Rα (benralizumab), rapidly depletes …

Mepolizumab and benralizumab are monoclonal antibodies (mAb) directed against anti-IL-5
and anti-IL5R, respectively, and their use reduces exacerbation rate and maintenance oral …

Several current guidelines/strategies outline a treatment approach to asthma, which
primarily consider the goals of improving lung function and quality of life and reducing …

Pulmonary functional magnetic resonance imaging (PfMRI) provides a way to non-invasively
map and measure the spatial distribution of pulmonary ventilation, perfusion and gas …

Airway mucus is a hydrogel with unique biophysical properties due to its primary water
composition and a small proportion of large anionic glycoproteins or mucins. The …

Pulmonary functional MRI (PfMRI) using inhaled hyperpolarized, radiation‐free gases (such
as 3He and 129Xe) provides a way to directly visualize inhaled gas distribution and …

Background: The physiological importance of mucus plugs in computed tomography (CT)
imaging is being increasingly recognized. However, whether airway inflammation and …

Respiratory diseases are leading causes of death and disability in the world. While early
diagnosis is key, this has proven difficult due to the lack of sensitive and non-invasive tools …