Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are elucidated as
cells that can perpetuate themselves via autorestoration. These cells are highly resistant to …

Expressed by cancer stem cells of various epithelial cell origins, CD133 is an attractive
therapeutic target for cancers. Autologous chimeric antigen receptor-modified T-cell directed …

Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

Abstract CD133 (prominin-1), a pentaspan membrane glycoprotein, is one of the most well-
characterized biomarkers used for the isolation of cancer stem cells (CSCs). The presence …

Here, we demonstrate self-organized formation of apico-basally polarized cortical tissues
from ESCs using an efficient three-dimensional aggregation culture (SFEBq culture). The …

During the development of the mammalian central nervous system, neural stem cells and
their derivative progenitor cells generate neurons by asymmetric and symmetric divisions …

A major cause of the cerebral cortex expansion that occurred during evolution is the
increase in subventricular zone (SVZ) progenitors. We found that progenitors in the outer …

Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …

Neural stem cells (NSCs, B1 cells) are retained in the walls of the adult lateral ventricles but,
unlike embryonic NSCs, are displaced from the ventricular zone (VZ) into the subventricular …