Cutaneous melanoma (CM) is a highly aggressive and drug resistant solid tumor, showing
an impressive metabolic plasticity modulated by oncogenic activation. In particular …

Metastasis is a common phenomenon in the progression and dissemination of cancer. It is
estimated that metastasis accounts for 90% cancer-related mortality. Although the formation …

Background Glioblastoma (GBM) stemlike cells (GSCs) are thought to be responsible for the
maintenance and aggressiveness of GBM, the most common primary brain tumor in adults …

The expression, localization, and function of connexins, the protein subunits that comprise
gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap …

The development of brain metastases in patients with advanced stage melanoma is
common, but the molecular mechanisms responsible for their development are poorly …

Communication among cells via direct cell-cell contact by connexin gap junctions, or
between cell and extracellular environment via pannexin channels or connexin …

Connexin 43 (Cx43), a vital gap junction protein in tumor microenvironment (TME), is a
novel molecular target for melanoma chemotherapeutics due to its tumor suppressive …

Abstract Mahogunin Ring Finger 1 is an E3-ubiquitin ligase encoded by the color gene
MGRN1. Our previous in vitro and in vivo studies demonstrated that Mgrn1 deletion in …

The therapy resistance of pancreatic cancer is associated with the loss of gap junction
intercellular communication and connexin 43 expression. The broccoli isothiocyanate …

Patients with seemingly the same tumour can respond very differently to treatment. There
are strong, well-established effects of somatic mutations on drug efficacy, but there is at-most …