Most patients who die of cancer have disseminated disease that has become resistant to
multiple therapeutic modalities. Ample evidence suggests that the expression of ATP …

Glioblastoma is the most common malignant primary brain tumor in adults and is almost
invariably fatal. Despite our growing understanding of the various mechanisms underlying …

The multidrug transporter permeability (P)–glycoprotein is an adenosine triphosphate (ATP)–
binding cassette exporter responsible for clinical resistance to chemotherapy. P-glycoprotein …

The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …

ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …

Abstract P-glycoprotein (P-gp) is an ATP-binding cassette transporter that confers multidrug
resistance in cancer cells,. It also affects the absorption, distribution and clearance of cancer …

Multidrug resistance (MDR) is a unique phenomenon in thc study of cellular drug resistance.
Cell lines exhibiting this phenotype have been selected for resistance to a single cytotoxic …

The discovery and characterization of P-glycoprotein, an energy-dependent multidrug efflux
pump, as a mechanism of multidrug resistance in cancer is generally accepted as a …

Why some patients with seizures are successfully treated with antiepileptic drugs (AEDs)
and others prove medically intractable is not known. Inadequate intraparenchymal drug …

Enhanced drug efflux mediated by ABCB1 P-glycoprotein and related ATP-binding cassette
transporters is one of several mechanisms of multidrug resistance thought to impair …