Characterizing the physiological response of bacterial cells to antibiotic treatment is crucial
for the design of antibacterial therapies and for understanding the mechanisms of antibiotic …

Most microorganisms regulate their cell size. In this article, we review some of the
mathematical formulations of the problem of cell size regulation. We focus on coarse …

Evolutionarily divergent bacteria share a common phenomenological strategy for cell-size
homeostasis under steady-state conditions. In the presence of inherent physiological …

Many experiments show that the numbers of mRNA and protein are proportional to the cell
volume in growing cells. However, models of stochastic gene expression often assume …

Growth laws emerging from studies of cell populations provide essential constraints on the
global mechanisms that coordinate cell growth,–. The foundation of bacterial cell cycle …

Inside individual cells, expression of genes is inherently stochastic and manifests as cell-to-
cell variability or noise in protein copy numbers. Since proteins half-lives can be comparable …

The cell cycle is canonically described as a series of four consecutive phases: G1, S, G2,
and M. In single cells, the duration of each phase varies, but the quantitative laws that …

Rod-shaped bacterial cells can readily adapt their lengths and widths in response to
environmental changes. While many recent studies have focused on the mechanisms …

Establishing a quantitative connection between the population growth rate and the
generation times of single cells is a prerequisite for understanding evolutionary dynamics of …

The stochasticity of gene expression is manifested in the fluctuations of messenger
ribonucleic acid and protein copy numbers within a cell lineage over time. While data of this …