Crocin, an active ingredient derived from saffron, is one of the herbal components that has
recently been considered by researchers. Crocin has been shown to have many anti …

Crocin, a water-soluble carotenoid, is known as a pharmacologically active compound,
particularly for its potent anti-oxidant activity. The present work provides a comprehensive …

Simple Summary Liver cancer represents one of the most lethal forms of cancer, with
hepatocellular carcinoma (HCC) accounting for the majority of its incidences and deaths …

Background Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-
metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive …

We aimed to investigate whether carnosine (a natural dipeptide found in humans) and
crocin (a natural product extracted from saffron and gardenia) can prevent the harmful …

When used as an alternative source of drugs to treat inflammation‐associated diseases,
phytochemicals with anti‐inflammatory properties provide beneficial impacts. Galangin is …

Introduction In multiple studies, involvement of oxidative stress in the pathogenesis of
methotrexate (MTX)-mediated liver damage has been confirmed. Use of many drugs has …

Methotrexate (MTX) is used as an effective chemotherapeutic agent against autoimmune
diseases and tumors. Oxidative stress and inflammation are involved in the pathogenesis of …

Despite unprecedented advances in modern medicine, no safe and effective drug is
available to date for oral administration to combat drug-induced liver injury, which is a vital …

Non‑alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin
resistance and inflammation; however, the exact pathogenesis of NAFLD is not fully …