Amide bond formation, the essential condensation reaction underlying peptide synthesis, is
hindered in aqueous systems by the thermodynamic constraints associated with …

Microdroplets show unique chemistry, especially in their intrinsic redox properties, and to
this we here add a case of simultaneous and spontaneous oxidation and reduction. We …

Contact electrification (CE) in water has attracted much attention, owing to its potential
impacts on the chemical reactions, such as the recent discovery of spontaneous generation …

The sulfur fluoride exchange (SuFEx) reaction is significant in drug discovery, materials
science, and chemical biology. Conventionally, it involves installation of SO2F followed by …

Ammonia (NH3) is one of the most widely used materials in the chemical industry. Here, we
report a proof-of-concept study on in situ synthesis and measurement of NH3 from nitrogen …

The esterification reaction of different amino acids with methanol catalyzed by H2SO4 was
first studied in the small volume of thin films generated by ESI microdroplet deposition. The …

Background Timely diagnosis and prevention of diseases require rapid and sensitive
detection of biomarkers from blood samples without external interference. Abnormal …

Chemical reactions in micron-sized droplets under ambient conditions are often orders of
magnitude faster than the equivalent bulk reactions due to the large interfacial effects. The …

The rapid analysis of complex samples using mass spectrometry (MS) provides valuable
information in both point-of-care (eg drug testing) and laboratory-based applications …