SOX9 is a pivotal transcription factor in chondrocytes, a lineage essential in skeletogenesis.
Its mandatory role in transactivating many cartilage-specific genes is well established …

Post-translational modifications are at the apex of cellular communication and eventually
regulate every aspect of life. The identification of new post-translational modifiers is opening …

Selective autophagy of organelles is critical for cellular differentiation, homeostasis, and
organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but …

Abstract p53 is the most intensively studied tumour suppressor. The regulation of p53
homeostasis is essential for its tumour-suppressive function,. Although p53 is regulated by …

Ubiquitin fold modifier 1 (UFM1) is a small, metazoan-specific, ubiquitin-like protein modifier
that is essential for embryonic development. Although loss-of-function mutations in UFM1 …

The transcription factor SOX9 is essential for the development of multiple organs including
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …

Post-translational modifications (PTMs) add a major degree of complexity to the proteome
and are essential controllers of protein homeostasis. Amongst the hundreds of PTMs …

Summary Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated
with intracellular proteins through UFMylation, a process similar to ubiquitylation. Growing …

SOX transcription factors participate in the specification, differentiation and activities of many
cell types in development and beyond. The 20 mammalian family members are distributed …

Chemoresistance is the main obstacle in osteosarcoma (OS) treatment; however, the
underlying mechanism remains unclear. In this study, it is discovered that DDRGK domain …