Therapeutic strategies for hepatitis B virus infection: towards a cure

GC Fanning, F Zoulim, J Hou, A Bertoletti - Nature reviews Drug …, 2019 - nature.com
Chronic hepatitis B virus (HBV) infection is a common cause of liver disease globally, with a
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …

A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook

A Kramvis, KM Chang, M Dandri, P Farci… - Nature Reviews …, 2022 - nature.com
Globally, 296 million people are infected with hepatitis B virus (HBV), and approximately one
million people die annually from HBV-related causes, including liver cancer. Although there …

A global scientific strategy to cure hepatitis B

PA Revill, FV Chisari, JM Block, M Dandri… - The lancet …, 2019 - thelancet.com
Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same
scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE …

Global burden of NAFLD and chronic liver disease among adolescents and young adults

JM Paik, K Kabbara, KE Eberly, Y Younossi, L Henry… - Hepatology, 2022 - journals.lww.com
Conclusions HBV cccDNA minichromosomes in distinct epigenetic transcriptional states
showed a similar reduction rate during cell division but significantly differed in their …

[HTML][HTML] Update of the statements on biology and clinical impact of occult hepatitis B virus infection

G Raimondo, S Locarnini, T Pollicino, M Levrero… - Journal of …, 2019 - Elsevier
In October 2018 a large number of international experts with complementary expertise came
together in Taormina to participate in a workshop on occult hepatitis B virus infection (OBI) …

Hepatitis B reactivation associated with immune suppressive and biological modifier therapies: current concepts, management strategies, and future directions

R Loomba, TJ Liang - Gastroenterology, 2017 - Elsevier
Hepatitis B reactivation associated with immune-suppressive and biological therapies is
emerging to be an important cause of morbidity and mortality in patients with current or prior …

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

M Nassal - Gut, 2015 - gut.bmj.com
At least 250 million people worldwide are chronically infected with HBV, a small
hepatotropic DNA virus that replicates through reverse transcription. Chronic infection …

Serum hepatitis B core-related antigen (HBcrAg) correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients

B Testoni, F Lebossé, C Scholtes, F Berby… - Journal of …, 2019 - Elsevier
Background & Aims It has been proposed that serum hepatitis B core-related antigen
(HBcrAg) reflects intrahepatic covalently closed circular (ccc) DNA levels. However, the …

Hepatitis B virus persistence and reactivation

Y Shi, M Zheng - bmj, 2020 - bmj.com
Hepatitis B virus (HBV) infection causes chronic hepatitis and has long term complications.
Individuals ever infected with HBV are at risk of viral reactivation under certain …

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

H Yan, G Zhong, G Xu, W He, Z Jing, Z Gao, Y Huang… - elife, 2012 - elifesciences.org
Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public
health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more …