Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Alterations in protein ubiquitylation and hypoxia are commonly associated with cancer.
Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be …

Increasing evidence has confirmed that deubiquitinating enzymes play an important role in
lung cancer progression. In the current study, we investigated the expression profile of …

Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …

Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …

Metastatic progression is the main cause of mortality in breast cancer, necessitating the
determination of the molecular events driving this process for the development of new …

Resistance to platinum-based chemotherapy is a common event in patients with cancer,
generally associated with tumor dissemination and metastasis. Whether platinum treatment …

Ubiquitination represents a post-translational modification (PTM) essential for the
maintenance of cellular homeostasis. Ubiquitination is involved in the regulation of protein …

Increasing evidence reveals a close relationship between deubiquitinating enzymes (DUBs)
and cancer progression. In this study, we attempted to identify the roles and mechanisms of …

Identifying novel drug targets to overcome resistance to tyrosine kinase inhibitors (TKIs) and
eradicating leukemia stem/progenitor cells are required for the treatment of chronic …