The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …

The introduction of the in vitro evolution method known as SELEX (systematic evolution of
ligands by exponential enrichment) more than 30 years ago led to the conception of …

Abstract N 6-methyladenosine (m6A) is the most abundant RNA modification in mammalian
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …

Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …

Enhancers determine spatiotemporal gene expression programs by engaging with long-
range promoters,,–. However, it remains unknown how enhancers find their cognate …

In contrast to single-cell approaches for measuring gene expression and DNA accessibility,
single-cell methods for analyzing histone modifications are limited by low sensitivity and …

INTRODUCTION Complex multicellular organisms are subject to a myriad of cellular
stresses, which can be managed through cell-intrinsic adaptation and repair mechanisms …

INTRODUCTION Interferons (IFNs) are cytokines that are rapidly deployed in response to
invading pathogens. By initiating a signaling cascade that stimulates the expression of …

INTRODUCTION Discrimination of self from nonself is pivotal for cellular organisms, as it
allows the perception of pathogenic invaders that might otherwise multiply unchecked and …

The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) disease (COVID-19)
pandemic has caused millions of deaths worldwide. Genome-wide association studies …