Cancer with a complex pathological process is a major disease to human welfare. Due to
the imbalance between oxygen (O2) supply and consumption, hypoxia is a natural …

Hypoxia is a common feature of solid tumors that contributes to angiogenesis, invasiveness,
metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor …

Inadequate oxygenation is a major challenge in cell encapsulation, a therapy which holds
potential to treat many diseases including type I diabetes. In such systems, cellular oxygen …

Abstract Type 1 diabetes (T1D) is an autoimmune disease that leads to the loss of insulin-
producing beta cells. Bioartificial pancreas (BAP) or beta cell replacement strategies have …

Purpose It has been known for over 100 years that tumor hypoxia, a near-universal
characteristic of solid tumors, decreases the curative effectiveness of radiation therapy …

Tumor hypoxia is recognized as a limiting factor for the efficacy of radiotherapy, because it
enhances tumor radioresistance. It is strongly suggested that assessing tumor oxygenation …

Systematic studies on the oxygenation status of solid tumors have shown that the
development of hypoxic/anoxic tissue subvolumes is a pathophysiological trait in a wide …

Background Clinical attempts to find benefit from specifically targeting and boosting resistant
hypoxic tumor subvolumes have been promising but inconclusive. While a first preclinical …

The purpose of this study was to assess the natural partial oxygen pressure (pO2) of
subcutaneous (SC) and intraperitoneal (IP) sites in mice to determine their relative suitability …

Significance: Oxygen imaging techniques, which can probe the spatiotemporal
heterogeneity of tumor oxygenation, could be of significant clinical utility in radiation …