Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Solubility has a crucial role in the success of a drug candidate. Compounds with low
solubility not only cause problems for in vitro and in vivo assays, but also add significant …

The aim of this research is the development of a new type of intra-articularly injectable
thermo-sensitive hydrogels for the long-term delivery of Piroxicam (PX). The thermo …

Background Inorganic nanoparticles provide promising tools for biomedical applications
including detection, diagnosis and therapy. While surface properties such as charge are …

Interest in intranasal (IN) administration as a non-invasive route for drug delivery continues
to grow rapidly. The nasal mucosa offers numerous benefits as a target issue for drug …

Highlights•Around half of the new molecular entities approved by the US Food and Drug
Administration are pharmaceutical salts.•The drug-approval database contains 61 …

The Orange Book database published by the US Drug and Food Administration (FDA) was
analyzed for the frequency of occurrence of different counterions used for the formation of …

From crystal structure prediction to totally empirical screening, the quest for new crystal
forms has become one of the most challenging issues in the solid state science and …

As cancer poses a significant threat to the well-being of humans on a global scale, many
researchers have embarked on the search for effective anticancer therapeutic agents. In …

A crystal engineering method was used to investigate cocrystal formation of piroxicam with
pharmaceutically acceptable carboxylic acids. Forming cocrystals of piroxicam can …