The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?

JS Boomer, JM Green, RS Hotchkiss - Virulence, 2014 - Taylor & Francis
Sepsis remains the leading cause of death in most intensive care units. Advances in
understanding the immune response to sepsis provide the opportunity to develop more …

[HTML][HTML] Epstein–Barr virus-associated lymphoproliferative disease in non-immunocompromised hosts: a status report and summary of an international meeting, 8–9 …

JI Cohen, H Kimura, S Nakamura, YH Ko, ES Jaffe - Annals of Oncology, 2009 - Elsevier
Abstract Background Recently novel Epstein–Barr virus (EBV) lymphoproliferative diseases
(LPDs) have been identified in non-immunocompromised hosts, both in Asia and Western …

EBV-associated T/NK–cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases

H Kimura, Y Ito, S Kawabe, K Gotoh… - Blood, The Journal …, 2012 - ashpublications.org
Abstract EBV-associated T/NK–cell lymphoproliferative disease (T/NK-LPD) is defined as a
systemic illness characterized by clonal proliferation of EBV-infected T or NK cells. We …

Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D

B Chaigne-Delalande, FY Li, GM O'Connor, MJ Lukacs… - Science, 2013 - science.org
The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free
magnesium (Mg2+) concentrations. Individuals with genetic deficiencies in MAGT1 have …

Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States

JI Cohen, ES Jaffe, JK Dale, S Pittaluga… - Blood, The Journal …, 2011 - ashpublications.org
Chronic active EBV disease (CAEBV) is a lymphoproliferative disorder characterized by
markedly elevated levels of antibody to EBV or EBV DNA in the blood and EBV RNA or …

Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients

T Oyama, K Yamamoto, N Asano, A Oshiro… - Clinical Cancer …, 2007 - AACR
Purpose: We have recently reported EBV+ B-cell lymphoproliferative disorders (LPD)
occurring predominantly in elderly patients, which shared features of EBV+ B-cell …

Proposed guidelines for diagnosing chronic active Epstein‐Barr virus infection

M Okano, K Kawa, H Kimura, A Yachie… - American journal of …, 2005 - Wiley Online Library
Since the initial report of unusual manifestations possibly associated with chronic active
Epstein‐Barr virus (EBV) infection (CAEBV), nearly three decades have passed. During this …

Inherited CD70 deficiency in humans reveals a critical role for the CD70–CD27 pathway in immunity to Epstein-Barr virus infection

K Izawa, E Martin, C Soudais, J Bruneau… - Journal of Experimental …, 2017 - rupress.org
Epstein-Barr virus (EBV) infection in humans is a major trigger of malignant and
nonmalignant B cell proliferations. CD27 is a co-stimulatory molecule of T cells, and …

CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia

JM Van Montfrans, AIM Hoepelman, S Otto… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: CD27 is a lymphocyte costimulatory molecule that regulates T-cell, natural
killer (NK) cell, B-cell, and plasma cell function, survival, and differentiation. On the basis of …

Prognostic factors for chronic active Epstein-Barr virus infection

H Kimura, T Morishima, H Kanegane… - The Journal of …, 2003 - academic.oup.com
Abstract Chronic active Epstein-Barr virus infection (CAEBV) is a high-mortality and high-
morbidity disease. To clarify the prognostic factors, a national survey was performed in …