The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

The YAP and TAZ paralogs are transcriptional co-activators recruited to target sites by TEAD
proteins. Here, we show that YAP and TAZ are also recruited by JUNB (a member of the AP …

Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor,
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …

The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif
(TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play …

With a 5-year survival rate of approximately 10%, pancreatic ductal adenocarcinoma
(PDAC) is one of the most lethal solid malignancies in humans. A poor understanding of the …

Lung cancer is the second most frequently diagnosed cancer worldwide and a leading
cause of cancer-related deaths. Non-small cell lung carcinoma (NSCLC) represents 85% of …

Hippo effectors YAP and TAZ control cell fate and survival through various mechanisms,
including transcriptional regulation of key genes. However, much of this research has been …

Accumulating evidence has underscored the importance of the Hippo‐YAP1 signaling in
lung tissue homeostasis, whereas its deregulation induces tumorigenesis. YAP1 and its …

The transcriptional regulators YAP and TAZ are involved in numerous physiological
processes including organ development, growth, immunity and tissue regeneration. YAP …