The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …

Parkinson's disease (PD) is the second most important age-related neurodegenerative
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …

Genome-wide association studies of neurological diseases have identified thousands of
variants associated with disease phenotypes. However, most of these variants do not alter …

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed
whole-genome sequencing in large cohorts of LBD cases and neurologically healthy …

The prevalence of neurodegenerative disease has increased significantly in recent years,
and with a rapidly aging global population, this trend is expected to continue. These …

We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …

Almost two decades after the identification of SNCA as the first causative gene in
Parkinson's disease (PD) and the subsequent understanding that genetic factors play a …

Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of
those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with …

Symptoms of Parkinson's disease arise due to neuronal loss in multiple brain regions,
especially dopaminergic neurons in the substantia nigra pars compacta. Current therapies …

Parkinson's disease (PD) is the second most common neurodegenerative disease, the main
pathological hallmark of which is the accumulation of α-synuclein (α-syn) and the formation …