An overview of the co-transcription factor NACC1: beyond its pro-tumor effects
Q Xie, C Tong, X Xiong - Life Sciences, 2024 - Elsevier
Nucleus accumbens-associated protein 1 (NACC1) is a member of the broad complex,
tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) protein families, mainly exerting its …
tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) protein families, mainly exerting its …
Targeting post-translational modifications of foxp3: A new paradigm for regulatory T cell-specific therapy
F Riaz, Z Huang, F Pan - Frontiers in Immunology, 2023 - frontiersin.org
A healthy immune system is pivotal for the hosts to resist external pathogens and maintain
homeostasis; however, the immunosuppressive tumor microenvironment (TME) damages …
homeostasis; however, the immunosuppressive tumor microenvironment (TME) damages …
Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion
Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in
transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can …
transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can …
[HTML][HTML] PIM kinases regulate early human Th17 cell differentiation
T Buchacher, A Shetty, SA Koskela, J Smolander… - Cell Reports, 2023 - cell.com
The serine/threonine-specific Moloney murine leukemia virus (PIM) kinase family (ie, PIM1,
PIM2, and PIM3) has been extensively studied in tumorigenesis. PIM kinases are …
PIM2, and PIM3) has been extensively studied in tumorigenesis. PIM kinases are …
[HTML][HTML] Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion
Background T cell-mediated antitumor immunity has a vital role in cancer prevention and
treatment; however, the immune-suppressive tumor microenvironment (TME) constitutes a …
treatment; however, the immune-suppressive tumor microenvironment (TME) constitutes a …
NAC1 confines virus‐specific memory formation of CD4+ T cells through the ROCK1‐mediated pathway
Nucleus accumbens‐associated protein 1 (NAC1), a transcriptional cofactor, has been
found to play important roles in regulating regulatory T cells, CD8+ T cells, and antitumor …
found to play important roles in regulating regulatory T cells, CD8+ T cells, and antitumor …
Melanoma-intrinsic NR2F6 activity regulates antitumor immunity
Nuclear receptors (NRs) are implicated in the regulation of tumors and immune cells. We
identify a tumor-intrinsic function of the orphan NR, NR2F6, regulating antitumor immunity …
identify a tumor-intrinsic function of the orphan NR, NR2F6, regulating antitumor immunity …
Expression of NAC1 Restrains the Memory Formation of CD8+ T Cells during Viral Infection
Nucleus accumbens-associated protein 1 (NAC1) is a transcription co-factor that has been
shown to possess multiple roles in stem cell and cancer biology. However, little is known …
shown to possess multiple roles in stem cell and cancer biology. However, little is known …
Identification of a NACC1-regulated gene signature implicated in the features of triple-negative breast cancer
Triple-negative breast cancer (TNBC), characterized by a deficiency in estrogen receptor
(ER), progesterone receptor (PR), and human epidermal growth factor receptor2 (HER2), is …
(ER), progesterone receptor (PR), and human epidermal growth factor receptor2 (HER2), is …
Acetylation model predicts prognosis of patients and affects immune microenvironment infiltration in epithelial ovarian carcinoma
X Wang, X Li, L Wei, Y Yu, Y Hazaisihan, L Tao… - Journal of Ovarian …, 2024 - Springer
Background Epithelial ovarian carcinoma (EOC) is a prevalent gynaecological malignancy.
The prognosis of patients with EOC is related to acetylation modifications and immune …
The prognosis of patients with EOC is related to acetylation modifications and immune …