Multicellular tumor spheroids: an underestimated tool is catching up again
F Hirschhaeuser, H Menne, C Dittfeld, J West… - Journal of …, 2010 - Elsevier
The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …
and cocultures for implementation into state of the art anti-cancer therapy test platforms …
The cancer stem cell niche—there goes the neighborhood?
SM Cabarcas, LA Mathews… - International journal of …, 2011 - Wiley Online Library
The niche is the environment in which stem cells reside and is responsible for the
maintenance of unique stem cell properties such as self‐renewal and an undifferentiated …
maintenance of unique stem cell properties such as self‐renewal and an undifferentiated …
Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines
L Cao, Y Zhou, B Zhai, J Liao, W Xu, R Zhang, J Li… - BMC …, 2011 - Springer
Abstract Background Cancer stem cells (CSCs) are regarded as the cause of tumor
formation and recurrence. The isolation and identification of CSCs could help to develop …
formation and recurrence. The isolation and identification of CSCs could help to develop …
Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients
Z Liu, A Fusi, E Klopocki, A Schmittel, I Tinhofer… - Journal of translational …, 2011 - Springer
Background A limitation of positive selection strategies to enrich for circulating tumor cells
(CTCs) is that there might be CTCs with insufficient expression of the surface target marker …
(CTCs) is that there might be CTCs with insufficient expression of the surface target marker …
Is tumor growth sustained by rare cancer stem cells or dominant clones?
JM Adams, A Strasser - Cancer research, 2008 - AACR
A key issue for cancer biology and therapy is whether the relentless growth of a tumor is
driven by a substantial proportion of its cells or exclusively by a rare subpopulation …
driven by a substantial proportion of its cells or exclusively by a rare subpopulation …
HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells
A Pietras, LM Hansford, AS Johnsson… - Proceedings of the …, 2009 - National Acad Sciences
High hypoxia-inducible factor-2α (HIF-2α) protein levels predict poor outcome in
neuroblastoma, and hypoxia dedifferentiates cultured neuroblastoma cells toward a neural …
neuroblastoma, and hypoxia dedifferentiates cultured neuroblastoma cells toward a neural …
miRNA-34c-5p inhibits amphiregulin-induced ovarian cancer stemness and drug resistance via downregulation of the AREG-EGFR-ERK pathway
Epithelial ovarian cancer is the most lethal gynecological cancer mainly due to late
diagnosis, easy spreading and rapid development of chemoresistance. Cancer stem cells …
diagnosis, easy spreading and rapid development of chemoresistance. Cancer stem cells …
CD133 suppresses neuroblastoma cell differentiation via signal pathway modification
H Takenobu, O Shimozato, T Nakamura, H Ochiai… - Oncogene, 2011 - nature.com
Abstract CD133 (prominin-1) is a transmembrane glycoprotein expressed on the surface of
normal and cancer stem cells (tumor-initiating cells), progenitor cells, rod photoreceptor cells …
normal and cancer stem cells (tumor-initiating cells), progenitor cells, rod photoreceptor cells …
Neuroblastoma patient‐derived orthotopic xenografts retain metastatic patterns and geno‐and phenotypes of patient tumours
N Braekeveldt, C Wigerup, D Gisselsson… - … journal of cancer, 2015 - Wiley Online Library
Neuroblastoma is a childhood tumour with heterogeneous characteristics and children with
metastatic disease often have a poor outcome. Here we describe the establishment of …
metastatic disease often have a poor outcome. Here we describe the establishment of …
Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma
Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness
is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could …
is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could …