The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …

The niche is the environment in which stem cells reside and is responsible for the
maintenance of unique stem cell properties such as self‐renewal and an undifferentiated …

Abstract Background Cancer stem cells (CSCs) are regarded as the cause of tumor
formation and recurrence. The isolation and identification of CSCs could help to develop …

Background A limitation of positive selection strategies to enrich for circulating tumor cells
(CTCs) is that there might be CTCs with insufficient expression of the surface target marker …

A key issue for cancer biology and therapy is whether the relentless growth of a tumor is
driven by a substantial proportion of its cells or exclusively by a rare subpopulation …

High hypoxia-inducible factor-2α (HIF-2α) protein levels predict poor outcome in
neuroblastoma, and hypoxia dedifferentiates cultured neuroblastoma cells toward a neural …

Epithelial ovarian cancer is the most lethal gynecological cancer mainly due to late
diagnosis, easy spreading and rapid development of chemoresistance. Cancer stem cells …

Abstract CD133 (prominin-1) is a transmembrane glycoprotein expressed on the surface of
normal and cancer stem cells (tumor-initiating cells), progenitor cells, rod photoreceptor cells …

Neuroblastoma is a childhood tumour with heterogeneous characteristics and children with
metastatic disease often have a poor outcome. Here we describe the establishment of …

Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness
is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could …