Studies of bioactive lipids in general and sphingolipids in particular have intensified over the
past several years, revealing an unprecedented and unanticipated complexity of the …

Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Triple-negative breast cancer (TNBC) is associated with high recurrence rates, high
incidence of distant metastases, and poor overall survival (OS). Taxane and anthracycline …

Sphingolipids are a class of complex lipids containing a backbone of sphingoid bases,
namely the organic aliphatic amino alcohol sphingosine (Sph), that are essential …

Ferroptosis is a type of regulated cell death characterized by ROS accumulation and
devastating lipid peroxidation (LPO). The role of acid sphingomyelinase (ASM), a key …

Cancer is the second cause of death worldwide, exceeded only by cardiovascular diseases.
The prevalent treatment currently used against metastatic cancer is chemotherapy. Among …

Ceramide synthases (CerS) are key enzymes in the lipid metabolism of eukaryotic cells.
Their products, ceramides (Cer), are components of cellular membranes but also mediate …

Cell surface biochemical changes, notably excessive increase in outer leaflet sphingomyelin
(SM) content, are important in cancer initiation, growth, and immune evasion. Innumerable …

Sphingolipids have emerged as key regulatory molecules in cancer cell survival and death.
Although important roles of sphingolipids in breast cancer progression have been reported …

Background Cancer is an enormous global health burden, and should be effectively
addressed with better therapeutic strategies. Currently, over 60% of the clinically approved …