A review of methods and databases for metagenomic classification and assembly

FP Breitwieser, J Lu, SL Salzberg - Briefings in bioinformatics, 2019 - academic.oup.com
Microbiome research has grown rapidly over the past decade, with a proliferation of new
methods that seek to make sense of large, complex data sets. Here, we survey two of the …

Metagenomic approaches in microbial ecology: an update on whole-genome and marker gene sequencing analyses

AE Pérez-Cobas, L Gomez-Valero… - Microbial …, 2020 - microbiologyresearch.org
Metagenomics and marker gene approaches, coupled with high-throughput sequencing
technologies, have revolutionized the field of microbial ecology. Metagenomics is a culture …

metaSPAdes: a new versatile metagenomic assembler

S Nurk, D Meleshko, A Korobeynikov… - Genome …, 2017 - genome.cshlp.org
While metagenomics has emerged as a technology of choice for analyzing bacterial
populations, the assembly of metagenomic data remains challenging, thus stifling biological …

MaxBin 2.0: an automated binning algorithm to recover genomes from multiple metagenomic datasets

YW Wu, BA Simmons, SW Singer - Bioinformatics, 2016 - academic.oup.com
The recovery of genomes from metagenomic datasets is a critical step to defining the
functional roles of the underlying uncultivated populations. We previously developed …

MetaBAT, an efficient tool for accurately reconstructing single genomes from complex microbial communities

DD Kang, J Froula, R Egan, Z Wang - PeerJ, 2015 - peerj.com
Grouping large genomic fragments assembled from shotgun metagenomic sequences to
deconvolute complex microbial communities, or metagenome binning, enables the study of …

MaxBin: an automated binning method to recover individual genomes from metagenomes using an expectation-maximization algorithm

YW Wu, YH Tang, SG Tringe, BA Simmons, SW Singer - Microbiome, 2014 - Springer
Background Recovering individual genomes from metagenomic datasets allows access to
uncultivated microbial populations that may have important roles in natural and engineered …

MetaVelvet: an extension of Velvet assembler to de novo metagenome assembly from short sequence reads

T Namiki, T Hachiya, H Tanaka… - Proceedings of the 2nd …, 2011 - dl.acm.org
Motivation: An important step of" metagenomics" analysis is the assembly of multiple
genomes from mixed sequence reads of multiple species in a microbial community. Most …

High throughput sequencing methods and analysis for microbiome research

JM Di Bella, Y Bao, GB Gloor, JP Burton… - Journal of microbiological …, 2013 - Elsevier
High-throughput sequencing technology is rapidly improving in quality, speed and cost. It is
therefore becoming more widely used to study whole communities of prokaryotes in many …

Meta-IDBA: a de Novo assembler for metagenomic data

Y Peng, HCM Leung, SM Yiu, FYL Chin - Bioinformatics, 2011 - academic.oup.com
Motivation: Next-generation sequencing techniques allow us to generate reads from a
microbial environment in order to analyze the microbial community. However, assembling of …

Gut dysbiosis and muscle aging: searching for novel targets against sarcopenia

A Picca, F Fanelli, R Calvani, G Mulè… - Mediators of …, 2018 - Wiley Online Library
Advanced age is characterized by several changes, one of which is the impairment of the
homeostasis of intestinal microbiota. These alterations critically influence host health and …