Epigenetic regulation of ageing: linking environmental inputs to genomic stability
Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …
The laboratory domestication of Caenorhabditis elegans
Model organisms are of great importance to our understanding of basic biology and to
making advances in biomedical research. However, the influence of laboratory cultivation on …
making advances in biomedical research. However, the influence of laboratory cultivation on …
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges
B Piasecka, D Duffy, A Urrutia… - Proceedings of the …, 2018 - National Acad Sciences
The contribution of host genetic and nongenetic factors to immunological differences in
humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral …
humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral …
[HTML][HTML] Gene expression changes with age in skin, adipose tissue, blood and brain
Background Previous studies have demonstrated that gene expression levels change with
age. These changes are hypothesized to influence the aging rate of an individual. We …
age. These changes are hypothesized to influence the aging rate of an individual. We …
Worms under stress: C. elegans stress response and its relevance to complex human disease and aging
Many organisms have stress response pathways, components of which share homology
with players in complex human disease pathways. Research on stress response in the …
with players in complex human disease pathways. Research on stress response in the …
From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation
Although many studies have examined quantitative trait variation across many species, only
a small number of genes and thereby molecular mechanisms have been discovered …
a small number of genes and thereby molecular mechanisms have been discovered …
Programming of plant leaf senescence with temporal and inter-organellar coordination of transcriptome in Arabidopsis
Plant leaves, harvesting light energy and fixing CO2, are a major source of foods on the
earth. Leaves undergo developmental and physiological shifts during their lifespan, ending …
earth. Leaves undergo developmental and physiological shifts during their lifespan, ending …
[PDF][PDF] Natural genetic variation as a tool for discovery in Caenorhabditis nematodes
EC Andersen, MV Rockman - Genetics, 2022 - academic.oup.com
Over the last 20 years, studies of Caenorhabditis elegans natural diversity have
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …
[HTML][HTML] Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation
Trans-acting DNA variants may specifically affect mRNA or protein levels of genes located
throughout the genome. However, prior work compared trans-acting loci mapped in …
throughout the genome. However, prior work compared trans-acting loci mapped in …
Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort
Abstract Changes in the mean and variance of gene expression with age have
consequences for healthy aging and disease development. Age-dependent changes in …
consequences for healthy aging and disease development. Age-dependent changes in …