Dengue is a vector-borne viral disease caused by the flavivirus dengue virus (DENV).
Approximately 400 million cases and 22 000 deaths occur due to dengue worldwide each …

Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …

The pathogenesis of dengue virus infection is attributed to complex interplay between virus,
host genes and host immune response. Host factors such as antibody-dependent …

Mortality from severe dengue is low, but the economic and resource burden on health
services remains substantial in endemic settings. Unfortunately, progress towards …

Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …

Background Dengue is an arboviral disease caused by dengue virus. Symptomatic dengue
infection causes a wide range of clinical manifestations, from mild dengue fever (DF) to …

Infection with any of the 4 dengue virus serotypes results in a diverse range of symptoms,
from mild undifferentiated fever to life-threatening hemorrhagic fever and shock. Given that …

Toll‐like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs).
They are highly conserved receptors that recognize conserved pathogen‐associated …

Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of
outbreaks accompanied by unexpectedly severe clinical complications brought this virus …

Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and
sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There …