Cryogenic contrast-enhanced microCT enables nondestructive 3D quantitative histopathology of soft biological tissues

A Maes, C Pestiaux, A Marino, T Balcaen… - Nature …, 2022 - nature.com
Biological tissues comprise a spatially complex structure, composition and organization at
the microscale, named the microstructure. Given the close structure-function relationships in …

Polarization microscopy for characterizing fiber orientation of ocular tissues

NJ Jan, JL Grimm, H Tran, KL Lathrop… - Biomedical optics …, 2015 - opg.optica.org
Characterizing the collagen fiber orientation and organization in the eye is necessary for a
complete understanding of ocular biomechanics. In this study, we assess the performance of …

Methods of Monitoring Cell Fate and Tissue Growth in Three-Dimensional Scaffold-Based Strategies for In Vitro Tissue Engineering

AM Leferink, CA van Blitterswijk… - Tissue Engineering Part B …, 2016 - liebertpub.com
In the field of tissue engineering, there is a need for methods that allow assessing the
performance of tissue-engineered constructs noninvasively in vitro and in vivo. To date …

Hierarchical structure of collagen composite systems: lessons from biology

E Baer, JJ Cassidy, A Hiltner - Pure and Applied Chemistry 33rd, 1991 - degruyter.com
Abstragt-Hierarchical structure in biocomposite systems such as in collagenous connective
tissue have many scales or levels, have highly specific interactions between these levels …

[HTML][HTML] Magic angle–enhanced MRI of fibrous microstructures in sclera and cornea with and without intraocular pressure loading

LC Ho, IA Sigal, NJ Jan, A Squires… - … & visual science, 2014 - tvst.arvojournals.org
Purpose.: The structure and biomechanics of the sclera and cornea are central to several
eye diseases such as glaucoma and myopia. However, their roles remain unclear, partly …

Single‐and bi‐component T2* analysis of tendon before and during tensile loading, using UTE sequences

EY Chang, J Du, K Iwasaki, R Biswas… - Journal of Magnetic …, 2015 - Wiley Online Library
Background To determine if the application of tensile force alters the single‐or bi‐
component T2* values of human tendons as measured on a clinical MRI scanner with …

Quantitative assessment of in vivo human anterior cruciate ligament autograft remodeling: a 3-dimensional UTE-T2* imaging study

RJ Warth, P Zandiyeh, M Rao… - … American Journal of …, 2020 - journals.sagepub.com
Background: The timing of return to play after anterior cruciate ligament (ACL) reconstruction
is still controversial due to uncertainty of true ACL graft state at the time of RTP. Recent work …

Non-invasive MRI assessments of tissue microstructures and macromolecules in the eye upon biomechanical or biochemical modulation

LC Ho, IA Sigal, NJ Jan, X Yang, Y Van Der Merwe… - Scientific reports, 2016 - nature.com
The microstructural organization and composition of the corneoscleral shell (CSS)
determine the biomechanical behavior of the eye, and are important in diseases such as …

Effects of Achilles tendon immersion in saline and perfluorochemicals on T2 and T2

EY Chang, J Du, WC Bae, S Statum… - Journal of Magnetic …, 2014 - Wiley Online Library
Purpose To determine if immersion of Achilles tendon segments into various solutions
improved qualitative delineation of tendon and affected quantitative MR values of T2 and …

Ultrashort echo imaging of cyclically loaded rabbit patellar tendon

MF Koff, SL Pownder, PH Shah, LW Yang… - Journal of …, 2014 - Elsevier
Tendinopathy affects individuals who perform repetitive joint motion. Magnetic resonance
imaging (MRI) is frequently used to qualitatively assess tendon health, but quantitative …