Genome-wide association studies (GWAS) aim to identify common genetic variants that are
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …

The vast majority of the genetic variants (mainly SNPs) associated with various human traits
and diseases map to a noncoding part of the genome and are enriched in its regulatory …

Background: The human heart requires a complex ensemble of specialized cell types to
perform its essential function. A greater knowledge of the intricate cellular milieu of the heart …

Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …

The stromal‐derived factor 1α/chemokine receptor 4 (SDF‐1α/CXCR4) axis contributes to
myocardial protection after myocardial infarction (MI) by recruiting endogenous stem cells …

Background: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable
cause of sudden cardiac death in the young. A causal rare genetic variant with large effect …

Aims The concept of “atrial cardiomyopathy”(AtCM) had been percolating through the
literature since its first mention in 1972. Since then, publications using the term were …

The electrocardiographic PR interval reflects atrioventricular conduction, and is associated
with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and …

Genome-wide association studies have uncovered over a 100 genetic loci associated with
atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci …

Background Drug development for atrial fibrillation (AF) has failed to yield new approved
compounds. We sought to identify and prioritise potential druggable targets with support …