Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
MC Duarte, DP Lage, VT Martins… - Revista da Sociedade …, 2016 - SciELO Brasil
Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide.
Although chemotherapy has been widely used to treat this disease, problems related to the …
Although chemotherapy has been widely used to treat this disease, problems related to the …
Visceral leishmaniasis: an overview of vaccine adjuvants and their applications
S Ratnapriya, AA Sahasrabuddhe, A Dube - Vaccine, 2019 - Elsevier
Although there has been an extensive research on vaccine development over the last
decade and some vaccines have been commercialized for canine visceral leishmaniasis …
decade and some vaccines have been commercialized for canine visceral leishmaniasis …
A candidate vaccine for human visceral leishmaniasis based on a specific T cell epitope-containing chimeric protein protects mice against Leishmania infantum …
DP Lage, PAF Ribeiro, DS Dias, DVC Mendonça… - npj Vaccines, 2020 - nature.com
Leishmaniases are neglected diseases caused by infection with Leishmania parasites and
there are currently no prophylactic vaccines. In this study, we designed in silico a synthetic …
there are currently no prophylactic vaccines. In this study, we designed in silico a synthetic …
A TLR9-adjuvanted vaccine formulated into dissolvable microneedle patches or cationic liposomes protects against leishmaniasis after skin or subcutaneous …
JS Lanza, S Vucen, O Flynn, A Donadei… - International Journal of …, 2020 - Elsevier
Re-emergence and geographic expansion of leishmaniasis is accelerating efforts to develop
a safe and effective Leshmania vaccine. Vaccines using Leishmania recombinant antigens …
a safe and effective Leshmania vaccine. Vaccines using Leishmania recombinant antigens …
Treatment of murine visceral leishmaniasis using an 8-hydroxyquinoline-containing polymeric micelle system
MC Duarte, LM dos Reis Lage, DP Lage… - Parasitology …, 2016 - Elsevier
New therapeutics are urgently needed to treat visceral leishmaniasis (VL). Due to the fact
that drug discovery is a long and expensive process, the development of delivery systems to …
that drug discovery is a long and expensive process, the development of delivery systems to …
Recombinant prohibitin protein of Leishmania infantum acts as a vaccine candidate and diagnostic marker against visceral leishmaniasis
DS Dias, PAF Ribeiro, VT Martins, DP Lage… - Cellular …, 2018 - Elsevier
Visceral leishmaniasis (VL) represents a serious public health problem, as Leishmania
infantum is one of main disease causative agents in the Americas. In a previous …
infantum is one of main disease causative agents in the Americas. In a previous …
A recombinant chimeric protein composed of human and mice‐specific CD4+ and CD8+ T‐cell epitopes protects against visceral leishmaniasis
VT Martins, MC Duarte, DP Lage, LE Costa… - Parasite …, 2017 - Wiley Online Library
In this study, a recombinant chimeric protein (RCP), which was composed of specific CD 4+
and CD 8+ T‐cell epitopes to murine and human haplotypes, was evaluated as an …
and CD 8+ T‐cell epitopes to murine and human haplotypes, was evaluated as an …
Antileishmanial activity and mechanism of action from a purified fraction of Zingiber officinalis Roscoe against Leishmania amazonensis
MC Duarte, GSV Tavares, DG Valadares… - Experimental …, 2016 - Elsevier
In recent years, considerable attention has been given to identify new antileishmanial
products derived from medicinal plants, although, to date, no new effective compound has …
products derived from medicinal plants, although, to date, no new effective compound has …
New Approaches to the Prevention of Visceral Leishmaniasis: A Review of Recent Patents of Potential Candidates for a Chimeric Protein Vaccine
DS Oliveira, MF Zaldívar, AAM Gonçalves, LA Resende… - Vaccines, 2024 - mdpi.com
The development of prophylactic vaccines is important in preventing and controlling
diseases such as visceral leishmaniasis (VL), in addition to being an economic measure for …
diseases such as visceral leishmaniasis (VL), in addition to being an economic measure for …
Vaccination with a CD4+ and CD8+ T-cell epitopes-based recombinant chimeric protein derived from Leishmania infantum proteins confers protective immunity …
DS Dias, PAF Ribeiro, VT Martins, DP Lage… - Translational …, 2018 - Elsevier
Vaccination seems to be the best approach to control visceral leishmaniasis (VL).
Resistance against infection is based on the development of a Th1 immune response …
Resistance against infection is based on the development of a Th1 immune response …