Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

A mosquito needs to ingest at least one male and one female gametocyte to become
infected with malaria. The sex of Plasmodium falciparum gametocytes can be determined …

Background Efficient allocation of resources to intervene against malaria requires a detailed
understanding of the contemporary spatial distribution of malaria risk. It is exactly 40 y since …

We assessed Plasmodium falciparum mdr1 (Pf mdr1) gene polymorphisms and copy
numbers as well as P. falciparum Ca2+ ATPase (Pf ATPase6) gene polymorphisms in 90 …

The isolation of artemisinin from the traditional medicinal herb qīng hāo (Artemisia annua),
its characterization as a peroxide and preparation of the derivatives dihydroartemisinin …

Background The use of artemisinin derivative-based combination therapy (ACT) such as
artesunate plus amodiaquine is currently recommended for the treatment of uncomplicated …

Malaria is among the leading public health problems worldwide. Female anopheles
mosquito orchestrates the transmission of malaria by taking gametocytes and introducing …

The scientific community worldwide has realized that malaria elimination will not be possible
without development of safe and effective transmission-blocking interventions. Primaquine …

Artemisinins are proposed to act in the malaria parasite cytosol by oxidizing dihydroflavin
cofactors of redox‐active flavoenzymes, and under aerobic conditions by inducing their …

Malaria parasites have evolved a complicated life cycle alternating between two hosts.
Gametocytes are produced in the vertebrate hosts and are obligatory for natural …