The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and
parasitic pathogens. Recognition of these unique glycans by the human immune system …

In the last decade, glycan microarrays have revolutionized the analysis of the specificity of
glycan-binding proteins (GBPs), providing information that simultaneously illuminates the …

Carbohydrate antigens are valuable as components of vaccines for bacterial infectious
agents and human immunodeficiency virus (HIV), and for generating immunotherapeutics …

Carbohydrate antigens have shown promise as important targets for developing effective
vaccines and pathogen detection strategies. Modifying purified microbial glycans through …

Diseases that result from infection are, in general, a consequence of specific interactions
between a pathogenic organism and the cells. The study of host-pathogen interactions has …

Shigella is the second most common etiologic pathogen responsible for childhood acute
diarrhea. An anti-Shigella vaccine is still eagerly awaited due to the increasing drug …

This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

Vaccines targeting glycan structures at the surface of pathogenic microbes must overcome
the inherent T cell–independent nature of immune responses against glycans. Carbohydrate …

Synthetic cell-surface glycans are promising vaccine candidates against Clostridium difficile.
The complexity of large, highly antigenic and immunogenic glycans is a synthetic challenge …

The human natural killer cell carbohydrate, HNK-1, plays function-conducive roles in
peripheral nerve regeneration and synaptic plasticity. It is also the target of autoantibodies in …