[HTML][HTML] Application of next generation sequencing in laboratory medicine
The rapid development of next-generation sequencing (NGS) technology, including
advances in sequencing chemistry, sequencing technologies, bioinformatics, and data …
advances in sequencing chemistry, sequencing technologies, bioinformatics, and data …
Within-host evolution of bacterial pathogens
Whole-genome sequencing has opened the way for investigating the dynamics and
genomic evolution of bacterial pathogens during the colonization and infection of humans …
genomic evolution of bacterial pathogens during the colonization and infection of humans …
Twenty years of bacterial genome sequencing
Twenty years ago, the publication of the first bacterial genome sequence, from Haemophilus
influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades …
influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades …
Genomic infectious disease epidemiology in partially sampled and ongoing outbreaks
Genomic data are increasingly being used to understand infectious disease epidemiology.
Isolates from a given outbreak are sequenced, and the patterns of shared variation are used …
Isolates from a given outbreak are sequenced, and the patterns of shared variation are used …
Definition of a genetic relatedness cutoff to exclude recent transmission of meticillin-resistant Staphylococcus aureus: a genomic epidemiology analysis
Background Whole-genome sequencing (WGS) can be used in genomic epidemiology
investigations to confirm or refute outbreaks of bacterial pathogens, and to support targeted …
investigations to confirm or refute outbreaks of bacterial pathogens, and to support targeted …
The evolutionary genomics of host specificity in Staphylococcus aureus
Staphylococcus aureus is an important human bacterial pathogen that has a cosmopolitan
host range, including livestock, companion and wild animal species. Genomic and …
host range, including livestock, companion and wild animal species. Genomic and …
Bacterial resistance to antimicrobial agents and its impact on veterinary and human medicine
This chapter focuses on acquired resistance mechanisms in bacterial pathogens of human
and animal origin, including examples of transfer of resistant pathogens between hosts and …
and animal origin, including examples of transfer of resistant pathogens between hosts and …
A year of infection in the intensive care unit: prospective whole genome sequencing of bacterial clinical isolates reveals cryptic transmissions and novel microbiota
Bacterial whole genome sequencing holds promise as a disruptive technology in clinical
microbiology, but it has not yet been applied systematically or comprehensively within a …
microbiology, but it has not yet been applied systematically or comprehensively within a …
From the pipeline to the bedside: advances and challenges in clinical metagenomics
A Dulanto Chiang, JP Dekker - The Journal of infectious …, 2020 - academic.oup.com
Next-generation sequencing (NGS) technologies have revolutionized multiple areas in the
field of infectious diseases, from pathogen discovery to characterization of genes mediating …
field of infectious diseases, from pathogen discovery to characterization of genes mediating …
Genomic insights into the emergence and spread of international clones of healthcare-, community-and livestock-associated meticillin-resistant Staphylococcus …
AM Bal, GW Coombs, MTG Holden, JA Lindsay… - Journal of Global …, 2016 - Elsevier
The evolution of meticillin-resistant Staphylococcus aureus (MRSA) from meticillin-
susceptible S. aureus has been a result of the accumulation of genetic elements under …
susceptible S. aureus has been a result of the accumulation of genetic elements under …