Metformin is a widely used biguanide drug due to its safety and low cost. It has been used
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …

Over the past 15 years, there has been great interest in the potential to repurpose the
diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts …

Metformin has been the mainstay of therapy for diabetes mellitus for many years; however,
the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed …

Metformin is a lipophilic biguanide which inhibits hepatic gluconeogenesis and improves
peripheral utilization of glucose. It is the first line pharmacotherapy for glucose control in …

Considerable efforts have been made since the 1950s to better understand the cellular and
molecular mechanisms of action of metformin, a potent antihyperglycaemic agent now …

Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …

Metformin has been designated as one of the most crucial first-line therapeutic agents in the
management of type 2 diabetes mellitus. Primarily being an antihyperglycemic agent …

Apoptosis plays important roles in the pathophysiology of Type 2 diabetes mellitus (T2DM).
The etiology of T2DM is multifactorial, including obesity-associated insulin resistance …

Polycystic ovary syndrome (PCOS) is now recognized to be the most common
endocrinopathy in women of reproductive age with a prevalence of 6.6–6.8%. PCOS, a …

Vitamin D deficiency is associated with a range of muscle disorders, including myalgia,
muscle weakness, and falls. In humans, polymorphisms of the vitamin D receptor (VDR) …