Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it
has been implicated in the pathogenesis of many diseases, there is evidence to support that …

Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and
cause neurological symptoms. Here we describe structural changes in cerebral small …

Summary Anti-interleukin-17 (IL-17) therapy has been used in various autoimmune
diseases. However, the efficacy is unexpectedly limited in several IL-17-associated …

Background Necroptosis, a recently discovered programmed cell death, has been
pathologically linked to various diseases and is thus a promising target for treating diseases …

As one of most common and severe mental disorders, major depressive disorder (MDD)
significantly increases the risks of premature death and other medical conditions for patients …

Microglia are so versatile that they not only provide immune surveillance for central nervous
system, but participate in neural circuitry development, brain blood vessels formation, blood …

Background Alzheimer's disease (AD) is the most common neurodegenerative disease.
Mitochondrial dysfunction and immune responses are important factors in the pathogenesis …

RIPK1 is a master regulator of inflammatory signaling and cell death and increased RIPK1
activity is observed in human diseases, including Alzheimer's disease (AD) and amyotrophic …

Current knowledge on Multiple Sclerosis (MS) etiopathogenesis encompasses complex
interactions between the host's genetic background and several environmental factors that …