Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

The tumor microenvironment plays a pivotal role in tumor initiation and progression by
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …

Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However,
during tumour progression and metastasis, cancerous epithelial cells must adapt to and …

Balancing cell death and survival is essential for normal development and homeostasis and
for preventing diseases, especially cancer. Conventional cell death pathways include …

Insulin-like growth factor-1 (IGF-1) and the IGF-1 receptor (IGF-1R) belong to the insulin-like
growth factor family, and IGF-1 activates intracellular signaling pathways by binding …

For cancer cells to survive during extracellular matrix (ECM) detachment, they must inhibit
anoikis and rectify metabolic deficiencies that cause non-apoptotic cell death. Previous …

Nontransformed cells that become detached from the extracellular matrix (ECM) undergo
dysregulation of redox homeostasis and cell death. In contrast, cancer cells often acquire the …

Insulin-like growth factor binding proteins (IGFBPs) and the associated signaling
components in the insulin-like growth factor (IGF) pathway regulate cell differentiation …

Integrin-mediated attachment to the extracellular matrix (ECM) is required to combat the
induction of programmed cell death in a variety of distinct cell types. If cells fail to maintain …

Loss of integrin-mediated attachment to extracellular matrix (ECM) proteins can trigger a
variety of cellular changes that affect cell viability. Foremost among these is the activation of …