An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver
disease (NAFLD) worldwide. NAFLD comprises different stadia going from isolated steatosis …

Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions
both in development and in pathological conditions. Here, we review the literature about the …

Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-
phosphate (S1P), are produced by the metabolism and perturbation of biological …

The phospholipase A2 (PLA2) superfamily of phospholipase enzymes hydrolyzes the ester
bond at the sn-2 position of the phospholipids, generating a free fatty acid and a …

Mono-and polyunsaturated lipids are widely distributed in Nature, and are structurally and
functionally a diverse class of molecules with a variety of physicochemical, biological …

Biochemical analyses reveal that plasma contains over 600 structural forms of lipid
molecules. This review summarizes known correlations between levels of lipid moieties and …

Membrane biology seeks to understand how lipids and proteins within bilayers assemble
into large structures such as organelles and the plasma membranes. Historically, lipids were …

The superfamily of phospholipase A2 (PLA2) enzymes currently consists of 15 Groups and
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …

Phosphatidic acid (PA) is a critical phospholipid constituent in eukaryotic cell membranes,
which accounts for 1À4% of the total lipid. 1 This lipophilic glycerophospholipid has a …

Numerous studies in humans link a nonsynonymous genetic polymorphism (I148M) in
adiponutrin (ADPN) to various forms of fatty liver disease and liver cirrhosis. Despite its high …