Somatostatin and somatostatin receptors
U Kumar, M Grant - Cellular peptide hormone synthesis and secretory …, 2010 - Springer
The biological effects of somatostatin (SST) were first encountered unexpectedly in the late
1960s in two unrelated studies, one by Krulich et al.(1968) who reported on a growth …
1960s in two unrelated studies, one by Krulich et al.(1968) who reported on a growth …
Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells.
FK506 (tacrolimus) is an immunosuppressive drug which interrupts Ca2+-calmodulin-
calcineurin signaling pathways in T lymphocytes, thereby blocking antigen activation of T …
calcineurin signaling pathways in T lymphocytes, thereby blocking antigen activation of T …
Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15.
A Moran, HJ Zhang, LK Olson… - The Journal of …, 1997 - Am Soc Clin Investig
Chronic exposure of HIT-T15 cells to supraphysiologic glucose concentration diminishes
insulin gene expression and decreased binding of two critical insulin gene transcription …
insulin gene expression and decreased binding of two critical insulin gene transcription …
Somatostatin and its receptors in the development of the endocrine pancreas
N Ballian, FC Brunicardi, XP Wang - Pancreas, 2006 - journals.lww.com
The development of the endocrine pancreas is regulated by numerous transcription and
growth factors. Somatostatin (SST) is present in many tissues and acts as a neurotransmitter …
growth factors. Somatostatin (SST) is present in many tissues and acts as a neurotransmitter …
Islet α-cells do not influence insulin secretion from β-cells through cell–cell contact
H Brereton, MJ Carvell, SJ Persaud, PM Jones - Endocrine, 2007 - Springer
Interactions between the endocrine cells in islets of Langerhans influence their secretory
function, and disruption of islet structure results in impaired insulin secretory responses to …
function, and disruption of islet structure results in impaired insulin secretory responses to …
Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway
SE Kahn, CB Verchere, DA D'Alessio, DL Cook… - Diabetologia, 1993 - Springer
To determine the potential for differential release of islet amyloid polypeptide and insulin, we
performed studies in rat islet monolayer cultures under conditions known to impair regulated …
performed studies in rat islet monolayer cultures under conditions known to impair regulated …
Regulation of human insulin gene transcription by glucose, epinephrine, and somatostatin
JB Redmon, HC Towle, RP Robertson - Diabetes, 1994 - Am Diabetes Assoc
We observed in the HIT cell, a clonal insulin-secreting cell line, that epinephrine and
somatostatin lower insulin mRNA levels and intracellular insulin content in addition to the …
somatostatin lower insulin mRNA levels and intracellular insulin content in addition to the …
Insulin gene expression and biosynthesis
V Poitout, R Stein, CJ Rhodes - International textbook of …, 2015 - Wiley Online Library
Insulin gene expression and proinsulin biosynthesis are highly regulated processes which
ensure that the pancreatic β cell maintains sufficient intracellular insulin stores to meet the …
ensure that the pancreatic β cell maintains sufficient intracellular insulin stores to meet the …
Somatostatin inhibits insulin-gene expression through a posttranscriptional mechanism in a hamster islet cell line
J Philippe - Diabetes, 1993 - Am Diabetes Assoc
Insulin secretion is regulated by the interplay of nutrients, local intraislet factors, and
hormones. Nutrients involved in the positive control of insulin secretion, such as glucose and …
hormones. Nutrients involved in the positive control of insulin secretion, such as glucose and …
Interaction of glucagon-like peptide-I (7–37) and somatostatin-14 on signal transduction and proinsulin gene expression in βTC-1 cells
HC Fehmann, M Strowski, B Göke - Metabolism, 1994 - Elsevier
The interactions of glucagon-like peptide-I (7–37)(7–36) amide (GLP-I) and somatostatin-14
were characterized on the cyclic adenosine monophosphate (cAMP)-dependent signal …
were characterized on the cyclic adenosine monophosphate (cAMP)-dependent signal …