Anticancer property of ginsenoside Rh2 from ginseng

X Li, S Chu, M Lin, Y Gao, Y Liu, S Yang, X Zhou… - European Journal of …, 2020 - Elsevier
Ginseng has been used as a well-known traditional Chinese medicine since ancient times.
Ginsenosides as its main active constituents possess a broad scope of pharmacological …

VDAC1, mitochondrial dysfunction, and Alzheimer's disease

V Shoshan-Barmatz, E Nahon-Crystal… - Pharmacological …, 2018 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an
accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have …

The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells

JH Lorent, J Quetin-Leclercq… - Organic & biomolecular …, 2014 - pubs.rsc.org
Saponins, amphiphiles of natural origin with numerous biological activities, are widely used
in the cosmetic and pharmaceutical industry. Some saponins exhibit relatively selective …

Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies

H Wang, Y Zheng, Q Sun, Z Zhang, M Zhao… - Journal of …, 2021 - Springer
Ginsenosides, the main components isolated from Panax ginseng, can play a therapeutic
role by inducing tumor cell apoptosis and reducing proliferation, invasion, metastasis; by …

Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure–Activity Relationships, and Molecular Mechanisms of Action

SA Nag, JJ Qin, W Wang, MH Wang, H Wang… - Frontiers in …, 2012 - frontiersin.org
Conventional chemotherapeutic agents are often toxic not only to tumor cells but also to
normal cells, limiting their therapeutic use in the clinic. Novel natural product anticancer …

Saponins from Chinese medicines as anticancer agents

XH Xu, T Li, CMV Fong, X Chen, XJ Chen, YT Wang… - Molecules, 2016 - mdpi.com
Saponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various
pharmacological effects against mammalian diseases. To promote the research and …

Plasma membrane lipid domains as platforms for vesicle biogenesis and shedding?

H Pollet, L Conrard, AS Cloos, D Tyteca - Biomolecules, 2018 - mdpi.com
Extracellular vesicles (EVs) contribute to several pathophysiological processes and appear
as emerging targets for disease diagnosis and therapy. However, successful translation from …

Ginsenoside 20 (S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathway in human colorectal cancer cells

S Han, AJ Jeong, H Yang, KB Kang, H Lee… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Panax ginseng is one of the most well-known medicinal
herbs in Korea and China, which has been used for treatment and prevention of cancer …

New generation of drug delivery systems based on ginsenoside Rh2-, Lysine-and Arginine-treated highly porous graphene for improving anticancer activity

H Zare-Zardini, A Taheri-Kafrani, A Amiri… - Scientific reports, 2018 - nature.com
In this study, Rh2–treated graphene oxide (GO-Rh2), lysine-treated highly porous graphene
(Gr-Lys), arginine-treated Gr (Gr-Arg), Rh2–treated Gr-Lys (Gr-Lys-Rh2) and Rh2–treated Gr …

Membrane rafts as a novel target in cancer therapy

A Hryniewicz-Jankowska, K Augoff… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Membrane rafts are distinct plasma membrane microdomains that are enriched in
sphingolipids and cholesterol. They organize receptors and their downstream molecules …