The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many
fundamental processes, including embryonic development and tissue homeostasis …

The zinc finger protein ZFYVE21 is involved in immune signaling. Using humanized mouse
models, primary human cells, and patient samples, we identified a T cell–autonomous role …

Recent studies have shown that T cells are not just the latecomers in inflammation but might
also play a key role in the early phase of this response. In this context, a number of T cell …

Abstract β-catenin is a central molecule in the Wnt pathway. Expression of a stable form of β-
catenin on CD4+ CD25+ regulatory T (Treg) cells resulted in a marked enhancement of …

Current cancer therapies target the bulk of the tumour, while a population of highly resistant
tumour cells may be able to repopulate the tumour and metastasize to new sites. Cancer …

Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast,
pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been …

Abstract Purpose: Basal cell carcinomas (BCCs) are tumors ignored by immune
surveillance. Activated Hedgehog (Hh) signaling within primary cilia is a key driver in the …

The production of mature functional T cells in the thymus requires signals from the thymic
epithelium. Here, we review recent experiments showing that one way in which the …

The Hedgehog (Hh) signaling pathway is pervasively involved in human malignancies,
making it an effective target for cancer treatment for decades. In addition to its direct role in …