Mechanisms of bone development and repair
A Salhotra, HN Shah, B Levi… - Nature reviews Molecular …, 2020 - nature.com
Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …
formation of the body scaffold. The repair potential of bone and its surrounding …
Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments
X Wei, Y Chen, X Jiang, M Peng, Y Liu, Y Mo, D Ren… - Molecular cancer, 2021 - Springer
Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process
found in many malignant tumors, and is different from the traditional angiogenetic process …
found in many malignant tumors, and is different from the traditional angiogenetic process …
Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
JR Hwang, Y Byeon, D Kim, SG Park - Experimental & molecular …, 2020 - nature.com
T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …
Microglia mediated neuroinflammation in Parkinson's disease
S Isik, B Yeman Kiyak, R Akbayir, R Seyhali, T Arpaci - Cells, 2023 - mdpi.com
Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen,
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …
The substrate repertoire of γ-secretase/presenilin
G Güner, SF Lichtenthaler - Seminars in cell & developmental biology, 2020 - Elsevier
The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …
Physical principles of membrane shape regulation by the glycocalyx
Cells bend their plasma membranes into highly curved forms to interact with the local
environment, but how shape generation is regulated is not fully resolved. Here, we report a …
environment, but how shape generation is regulated is not fully resolved. Here, we report a …
Building strong bones: molecular regulation of the osteoblast lineage
F Long - Nature reviews Molecular cell biology, 2012 - nature.com
The past 15 years have witnessed tremendous progress in the molecular understanding of
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …
Development of the endochondral skeleton
Much of the mammalian skeleton is composed of bones that originate from cartilage
templates through endochondral ossification. Elucidating the mechanisms that control …
templates through endochondral ossification. Elucidating the mechanisms that control …
[HTML][HTML] GSK-3 as potential target for therapeutic intervention in cancer
JA McCubrey, LS Steelman, FE Bertrand, NM Davis… - Oncotarget, 2014 - ncbi.nlm.nih.gov
The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …