Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

Microbiota-mediated colonization resistance: mechanisms and regulation

G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …

Unravelling the collateral damage of antibiotics on gut bacteria

L Maier, CV Goemans, J Wirbel, M Kuhn, C Eberl… - Nature, 2021 - nature.com
Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the
composition of gut microbiota and causing dysbiosis and disease. Despite this well-known …

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

LF Mager, R Burkhard, N Pett, NCA Cooke, K Brown… - Science, 2020 - science.org
Several species of intestinal bacteria have been associated with enhanced efficacy of
checkpoint blockade immunotherapy, but the underlying mechanisms by which the …

Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders

A Metwaly, S Reitmeier, D Haller - Nature reviews Gastroenterology & …, 2022 - nature.com
The intestine harbours a complex array of microorganisms collectively known as the gut
microbiota. The past two decades have witnessed increasing interest in studying the gut …

Microbiome diversity protects against pathogens by nutrient blocking

F Spragge, E Bakkeren, MT Jahn, E BN Araujo… - Science, 2023 - science.org
The human gut microbiome plays an important role in resisting colonization of the host by
pathogens, but we lack the ability to predict which communities will be protective. We …

Short-term dietary changes can result in mucosal and systemic immune depression

F Siracusa, N Schaltenberg, Y Kumar, TR Lesker… - Nature …, 2023 - nature.com
Omnivorous animals, including mice and humans, tend to prefer energy-dense nutrients rich
in fat over plant-based diets, especially for short periods of time, but the health …

Functional and genomic variation between human-derived isolates of Lachnospiraceae reveals inter-and intra-species diversity

MT Sorbara, ER Littmann, E Fontana, TU Moody… - Cell host & …, 2020 - cell.com
Bacteria belonging to the Lachnospiraceae family are abundant, obligate anaerobic
members of the microbiota in healthy humans. Lachnospiraceae impact their hosts by …

Sequence and cultivation study of Muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family

I Lagkouvardos, TR Lesker, TCA Hitch, EJC Gálvez… - Microbiome, 2019 - Springer
Background Bacteria within family S24-7 (phylum Bacteroidetes) are dominant in the mouse
gut microbiota and detected in the intestine of other animals. Because they had not been …

[HTML][HTML] A gut commensal-produced metabolite mediates colonization resistance to Salmonella infection

A Jacobson, L Lam, M Rajendram, F Tamburini… - Cell host & …, 2018 - cell.com
The intestinal microbiota provides colonization resistance against pathogens, limiting
pathogen expansion and transmission. These microbiota-mediated mechanisms were …