Microbiome-based therapeutics
MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
Microbiota-mediated colonization resistance: mechanisms and regulation
G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …
Unravelling the collateral damage of antibiotics on gut bacteria
Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the
composition of gut microbiota and causing dysbiosis and disease. Despite this well-known …
composition of gut microbiota and causing dysbiosis and disease. Despite this well-known …
Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy
Several species of intestinal bacteria have been associated with enhanced efficacy of
checkpoint blockade immunotherapy, but the underlying mechanisms by which the …
checkpoint blockade immunotherapy, but the underlying mechanisms by which the …
Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders
The intestine harbours a complex array of microorganisms collectively known as the gut
microbiota. The past two decades have witnessed increasing interest in studying the gut …
microbiota. The past two decades have witnessed increasing interest in studying the gut …
Microbiome diversity protects against pathogens by nutrient blocking
The human gut microbiome plays an important role in resisting colonization of the host by
pathogens, but we lack the ability to predict which communities will be protective. We …
pathogens, but we lack the ability to predict which communities will be protective. We …
Short-term dietary changes can result in mucosal and systemic immune depression
F Siracusa, N Schaltenberg, Y Kumar, TR Lesker… - Nature …, 2023 - nature.com
Omnivorous animals, including mice and humans, tend to prefer energy-dense nutrients rich
in fat over plant-based diets, especially for short periods of time, but the health …
in fat over plant-based diets, especially for short periods of time, but the health …
Functional and genomic variation between human-derived isolates of Lachnospiraceae reveals inter-and intra-species diversity
Bacteria belonging to the Lachnospiraceae family are abundant, obligate anaerobic
members of the microbiota in healthy humans. Lachnospiraceae impact their hosts by …
members of the microbiota in healthy humans. Lachnospiraceae impact their hosts by …
Sequence and cultivation study of Muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family
Background Bacteria within family S24-7 (phylum Bacteroidetes) are dominant in the mouse
gut microbiota and detected in the intestine of other animals. Because they had not been …
gut microbiota and detected in the intestine of other animals. Because they had not been …
[HTML][HTML] A gut commensal-produced metabolite mediates colonization resistance to Salmonella infection
A Jacobson, L Lam, M Rajendram, F Tamburini… - Cell host & …, 2018 - cell.com
The intestinal microbiota provides colonization resistance against pathogens, limiting
pathogen expansion and transmission. These microbiota-mediated mechanisms were …
pathogen expansion and transmission. These microbiota-mediated mechanisms were …