Global incidence of non-alcoholic fatty liver disease: A systematic review and meta-analysis of 63 studies and 1,201,807 persons

MH Le, DM Le, TC Baez, Y Wu, T Ito, EY Lee… - Journal of …, 2023 - Elsevier
Background & Aims The prevalence of non-alcoholic fatty liver disease (NAFLD) is
increasing. We aimed to estimate the pooled global NAFLD incidence. Methods We …

Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH)

A Do, F Zahrawi, WZ Mehal - Nature Reviews Drug Discovery, 2024 - nature.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its severe subgroup
metabolic dysfunction-associated steatohepatitis (MASH) have become a global epidemic …

Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population

J Ding, H Liu, X Zhang, N Zhao, Y Peng, J Shi… - Science Translational …, 2024 - science.org
Nonalcoholic fatty liver disease (NAFLD) has become a common health care burden
worldwide. The high heterogeneity of NAFLD remains elusive and impairs outcomes of …

[HTML][HTML] In vitro models for the study of liver biology and diseases: advances and limitations

S Kaur, S Kidambi, M Ortega-Ribera, N Nieto… - Cellular and molecular …, 2023 - Elsevier
In vitro models of liver (patho) physiology, new technologies, and experimental approaches
are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells …

Semaglutide has beneficial effects on non-alcoholic steatohepatitis in Ldlr-/-. Leiden mice

JA Inia, G Stokman, MC Morrison, N Worms… - International Journal of …, 2023 - mdpi.com
Semaglutide, a glucagon-like peptide-1 receptor agonist, is an antidiabetic medication that
has recently been approved for the treatment of obesity as well. Semaglutide is postulated to …

Nonalcoholic liver disease: epidemiology, risk factors, natural history, and management strategies

G Agyapong, F Dashti, BA Banini - … of the New York Academy of …, 2023 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is now the most common chronic liver disease
worldwide and a leading indication for liver transplantation in the United States. NAFLD …

Innovative therapeutic approaches in non-alcoholic fatty liver disease: When knowing your patient is key

M Alonso-Peña, M Del Barrio, A Peleteiro-Vigil… - International Journal of …, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disorders ranging
from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic steatosis may result …

Unique metabolomics characteristics for distinguishing cirrhosis related to different liver diseases: A systematic review and meta-analysis

L Yang, F Wang, S Liu, Z Xian, S Yang, Y Xu… - Diabetes & Metabolic …, 2024 - Elsevier
Background and aim Clinical evidence for early identification and diagnosis of liver cirrhosis
(LC) caused by different types of liver disease is limited. We investigated this topic through a …

Research priorities for precision medicine in NAFLD

P Iruzubieta, R Bataller, MT Arias-Loste… - Clinics in Liver …, 2023 - liver.theclinics.com
NAFLD and its inflammatory condition NASH, which is more likely to progress to fibrosis and
advanced liver disease, are the histologic manifestation of a heterogeneous disease closely …

Identifying patient subgroups in MASLD and MASH-associated fibrosis: molecular profiles and implications for drug development

MA González Hernández, L Verschuren… - Scientific Reports, 2024 - nature.com
The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide.
Drug therapy is hampered by large patient variability and partial representation of human …