Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

K-RAS signaling has been intensely studied for over 40 years. Yet, as of today, no drugs
have been approved to treat K-RAS mutant cancers. Since the turn of the century, scientists …

Approximately half of the world's population is infected with the stomach pathogen
Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer …

Abstract Fos-related antigen-1 (Fra-1) is a member of the activator protein-1 transcription
factor superfamily. It plays important roles in oncogenesis in various types of malignancies …

Non‑small cell lung cancer (NSCLC) is a major type of human lung cancer and the primary
cause of cancer‑associated cases of mortality worldwide. Phosphatase and tensin homolog …

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a lipid and protein
phosphatase and possesses an antitumor effect in lung cancers. miRNAs are reportedly …

Purpose: Plumbagin is thought to be a bioactive phytochemical drug and exerts an antitumor
effect on various cancers. However, few studies focus on the antitumor activity of plumbagin …

SIVA-1 has been shown to affect apoptotic processes in various different cell lines, and SIVA-
1 significantly contributes to the decreased responsiveness of cancer cells to some …

Background: Despite the prominent development of medical technology in recent years, the
prognosis of non-small cell lung cancer (NSCLC) is still not optimistic. It is crucial to identify …

Siva-1 is a well-known anti-apoptosis protein that serves a role in multiple types of cancer
cells. However, whether Siva-1 affects multidrug resistance via the NF-κB pathway in gastric …