Carotid body chemoreceptors: physiology, pathology, and implications for health and disease
R Iturriaga, J Alcayaga, MW Chapleau… - Physiological …, 2021 - journals.physiology.org
The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …
G-protein-coupled receptor (GPCR) signaling in the carotid body: roles in hypoxia and cardiovascular and respiratory disease
HS Aldossary, AA Alzahrani, D Nathanael… - International Journal of …, 2020 - mdpi.com
The carotid body (CB) is an important organ located at the carotid bifurcation that constantly
monitors the blood supplying the brain. During hypoxia, the CB immediately triggers an …
monitors the blood supplying the brain. During hypoxia, the CB immediately triggers an …
Long-term hypercaloric diet consumption exacerbates age-induced dysmetabolism and carotid body dysfunction: beneficial effects of CSN denervation
BF Melo, JF Sacramento, AM Capucho… - Frontiers in …, 2022 - frontiersin.org
Carotid bodies (CBs) are metabolic sensors whose dysfunction is involved in the genesis of
dysmetabolic states. Ageing induces significant alterations in CB function also prompting to …
dysmetabolic states. Ageing induces significant alterations in CB function also prompting to …
Mitochondrial succinate metabolism and reactive oxygen species are important but not essential for eliciting carotid body and ventilatory responses to hypoxia in the …
A Swiderska, AM Coney, AA Alzahrani, HS Aldossary… - Antioxidants, 2021 - mdpi.com
Reflex increases in breathing in response to acute hypoxia are dependent on activation of
the carotid body (CB)—A specialised peripheral chemoreceptor. Central to CB O2-sensing …
the carotid body (CB)—A specialised peripheral chemoreceptor. Central to CB O2-sensing …
Cardiovascular and respiratory evaluation in adenosine A2A receptor knockout mice submitted to short‐term sustained hypoxia
JR Souza, BH Machado - Experimental Physiology, 2023 - Wiley Online Library
Sustained hypoxia (SH) in mice induces changes in the respiratory pattern and increase in
the parasympathetic tone to the heart. Among adenosine G‐protein‐coupled receptors …
the parasympathetic tone to the heart. Among adenosine G‐protein‐coupled receptors …
LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response
The hypoxic ventilatory response (HVR) is critical to breathing and thus oxygen supply to the
body and is primarily mediated by the carotid bodies. Here we reveal that carotid body …
body and is primarily mediated by the carotid bodies. Here we reveal that carotid body …
Metabotropic Glutamate Receptors 1 Regulates Rat Carotid Body Response to Acute Hypoxia via Presynaptic Mechanism
C Li, B Zhao, C Zhao, L Huang, Y Liu - Frontiers in Neuroscience, 2021 - frontiersin.org
Background: The carotid body (CB) plays a critical role in oxygen sensing; however, the role
of glutamatergic signaling in the CB response to hypoxia remains uncertain. We previously …
of glutamatergic signaling in the CB response to hypoxia remains uncertain. We previously …
Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
Several studies demonstrated a link between obstructive sleep apnea (OSA) and the
development of insulin resistance. However, the main event triggering insulin resistance in …
development of insulin resistance. However, the main event triggering insulin resistance in …
Experimental Evidence of A2A–D2 Receptor–Receptor Interactions in the Rat and Human Carotid Body
Adenosine A2A receptors (A2AR) and dopamine D2 receptors (D2R) are known to be
involved in the physiological response to hypoxia, and their expression/activity may be …
involved in the physiological response to hypoxia, and their expression/activity may be …
The association between notching of the right ventricular outflow tract flow velocity doppler envelope and impaired right ventricular function after acute high-altitude …
F Yuan, C Liu, S Yu, S Bian, J Yang, X Ding… - Frontiers in …, 2021 - frontiersin.org
Introduction Pulmonary artery pressure (PAP) is increased and right ventricular (RV) function
is well preserved in healthy subjects upon exposure to high altitude (HA). An increase in …
is well preserved in healthy subjects upon exposure to high altitude (HA). An increase in …