Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated
tissue clones whose continued propagation is vested in a biologically distinct subset of cells …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Background Acquired aplastic anemia results from immune-mediated destruction of bone
marrow. Immunosuppressive therapies are effective, but reduced numbers of residual stem …

Despite its complexity, blood is probably the best understood developmental system, largely
due to seminal experimentation in the mouse. Clinically, hematopoietic stem cell (HSC) …

In the human hematopoietic system, aging is associated with decreased bone marrow
cellularity, decreased adaptive immune system function, and increased incidence of anemia …

Lifelong blood cell production is dependent on rare hematopoietic stem cells (HSCs) to
perpetually replenish mature cells via a series of lineage-restricted intermediates …

The mammalian blood system, containing more than 10 distinct mature cell types, stands on
one specific cell type, hematopoietic stem cell (HSC). Within the system, only HSCs possess …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

On the subject of acute myeloid leukemia (AML), there is little consensus about the target
cell within the hematopoietic stem cell hierarchy that is susceptible to leukemic …