[HTML][HTML] IL-6: Relevance for immunopathology of SARS-CoV-2

EO Gubernatorova, EA Gorshkova, AI Polinova… - Cytokine & growth factor …, 2020 - Elsevier
COVID-19 mortality is strongly associated with the development of severe pneumonia and
acute respiratory distress syndrome with the worst outcome resulting in cytokine release …

Cytokine release syndrome in COVID-19: a major mechanism of morbidity and mortality

Y Que, C Hu, K Wan, P Hu, R Wang, J Luo… - International reviews …, 2022 - Taylor & Francis
Abstract The coronavirus disease 2019 (COVID-19) triggered by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) erupted in Hubei Province of China in December …

Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension

J Meng, G Xiao, J Zhang, X He, M Ou, J Bi… - Emerging microbes & …, 2020 - Taylor & Francis
The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus
infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin …

Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

R Poduri, G Joshi, G Jagadeesh - Cellular signalling, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense,
single-stranded RNA virus that causes the potentially lethal Covid-19 respiratory tract …

Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications

N Banu, SS Panikar, LR Leal, AR Leal - Life sciences, 2020 - Elsevier
In light of the outbreak of the 2019 novel coronavirus disease (COVID-19), the international
scientific community has joined forces to develop effective treatment strategies. The …

Pulmonary angiotensin-converting enzyme 2 (ACE2) and inflammatory lung disease

H Jia - Shock, 2016 - journals.lww.com
In response to infectious and, in some instances, noninfectious insults, the affected
tissues/cells of the host undergo inflammation. However, uncontrolled inflammation could be …

[HTML][HTML] The pathobiology of myalgic encephalomyelitis/chronic fatigue syndrome: the case for neuroglial failure

H Renz-Polster, ME Tremblay, D Bienzle… - Frontiers in cellular …, 2022 - frontiersin.org
Although myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has a specific and
distinctive profile of clinical features, the disease remains an enigma because causal …

Targeting SARS-CoV-2 receptors as a means for reducing infectivity and improving antiviral and immune response: an algorithm-based method for overcoming …

R Gelman, A Bayatra, A Kessler… - Emerging microbes & …, 2020 - Taylor & Francis
The ongoing severe acute respiratory syndrome pandemic caused by the novel coronavirus
2 (SARS-CoV-2) is associated with high morbidity and mortality rates, and it has created a …

Myocyte signalling in leucocyte recruitment to the heart

A Ghigo, I Franco, F Morello, E Hirsch - Cardiovascular research, 2014 - academic.oup.com
Myocardial damage, by different noxious causes, triggers an inflammatory reaction driving
post-injury repair mechanisms and chronic remodelling processes that are largely …

COVID‐19 and renin‐angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2)‐Is there any scientific evidence for controversy?

A Aleksova, F Ferro, G Gagno… - Journal of Internal …, 2020 - Wiley Online Library
Renin–angiotensin system (RAS) blockers are extensively used worldwide to treat many
cardiovascular disorders, where they are effective in reducing both mortality and morbidity …