A critical review of white matter changes in Huntington's disease
Huntington's disease is a genetic neurodegenerative disorder. White matter alterations have
recently been identified as a relevant pathophysiological feature of Huntington's disease, but …
recently been identified as a relevant pathophysiological feature of Huntington's disease, but …
[HTML][HTML] Cell-autonomous and non-cell-autonomous pathogenic mechanisms in Huntington's disease: insights from in vitro and in vivo models
J Creus-Muncunill, ME Ehrlich - Neurotherapeutics, 2019 - Elsevier
Huntington's disease (HD) is an autosomal dominant disorder caused by an expansion in
the trinucleotide CAG repeat in exon-1 in the huntingtin gene, located on chromosome 4 …
the trinucleotide CAG repeat in exon-1 in the huntingtin gene, located on chromosome 4 …
Insights into white matter defect in Huntington's disease
Y Sun, H Tong, T Yang, L Liu, XJ Li, S Li - Cells, 2022 - mdpi.com
Huntington's disease (HD) is an autosomal-dominant inherited progressive
neurodegenerative disorder. It is caused by a CAG repeat expansion in the Huntingtin gene …
neurodegenerative disorder. It is caused by a CAG repeat expansion in the Huntingtin gene …
Combination of stem cell and gene therapy ameliorates symptoms in Huntington's disease mice
IK Cho, CE Hunter, S Ye, AL Pongos… - NPJ Regenerative …, 2019 - nature.com
Huntington's disease (HD) is a dominantly inherited monogenetic disorder characterized by
motor and cognitive dysfunction due to neurodegeneration. The disease is caused by the …
motor and cognitive dysfunction due to neurodegeneration. The disease is caused by the …
A molecular and cellular perspective on human brain evolution and tempo
The evolution of the modern human brain was accompanied by distinct molecular and
cellular specializations, which underpin our diverse cognitive abilities but also increase our …
cellular specializations, which underpin our diverse cognitive abilities but also increase our …
A biocompatible and injectable hydrogel to boost the efficacy of stem cells in neurodegenerative diseases treatment
Aims Stem cell therapies emerged as treatment modalities with potential to cure
neurodegenerative diseases (NDs). However, despite high expectations, their clinical use is …
neurodegenerative diseases (NDs). However, despite high expectations, their clinical use is …
Large animal models of Huntington's disease: what we have learned and where we need to go next
D Howland, Z Ellederova, N Aronin… - Journal of …, 2020 - content.iospress.com
Genetically modified rodent models of Huntington's disease (HD) have been especially
valuable to our understanding of HD pathology and the mechanisms by which the mutant …
valuable to our understanding of HD pathology and the mechanisms by which the mutant …
Amelioration of Huntington's disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington's disease monkeys
Huntington's disease (HD) is a devastating monogenic, dominant, hereditary,
neurodegenerative disease. HD is caused by the expansion of CAG repeats in exon 1 of the …
neurodegenerative disease. HD is caused by the expansion of CAG repeats in exon 1 of the …
A novel rhesus macaque model of Huntington's disease recapitulates key neuropathological changes along with motor and cognitive decline
We created a new nonhuman primate model of the genetic neurodegenerative disorder
Huntington's disease (HD) by injecting a mixture of recombinant adeno-associated viral …
Huntington's disease (HD) by injecting a mixture of recombinant adeno-associated viral …
Infantile iron deficiency affects brain development in monkeys even after treatment of anemia
A high percent of oxidative energy metabolism is needed to support brain growth during
infancy. Unhealthy diets and limited nutrition, as well as other environmental insults, can …
infancy. Unhealthy diets and limited nutrition, as well as other environmental insults, can …