What is known and objective Genetic polymorphism is one of the most important factors
responsible for interindividual and interethnic variability in drug response. Studies in major …

Purpose: The CYP2C19 isoenzyme plays an important role in the efficacy and safe use of
many drugs. The aim of this review is to demonstrate how CYP2C19 mutations influence …

Understanding the prevalence of clinically relevant pharmacogenetic variants using large
unselected populations is critical for gauging the potential clinical impact of widespread …

Background Cytochrome P450 (CYP) 2C19 is an enzyme involved in the bioactivation of
various important therapeutic drugs, from pro-drugs to an active inhibitor of platelet action …

Depression disorder is one of the most serious mental illnesses in the world. Escitalopram is
the essential first-line medication for depression disorder. It is the substrate of hepatic …

Background Poor metabolizer (PM) status of CYP2C19 can be a predisposing factor for
developing gastric cancer in H. pylori-infected patients. It is unclear whether PM status of …

Introduction Clopidogrel is a P2Y12 inhibitor that has become a mainstay treatment
following percutaneous intervention with drug-eluting stent placement to decrease …

ABSTRACT Introduction: Cytochrome P450 (CYP) is a monooxygenase superfamily
mediating the elimination of anti-hypertensive drugs. Polymorphisms of CYP would lead to …

Background Marked differences among genotype frequencies (Caucasians, Asians, and
Africans) have been observed in cytochrome P450 (CYP) genes. Data on the frequency of …

Terminalia chebula Retz.(TCR) is a medicinal material commonly used in Mongolian
medicine. After consulting the literature at home and abroad, current research on TCR …