Alloreactivity from human viral specific memory T-cells
LJA D'Orsogna, DL Roelen, IIN Doxiadis… - Transplant …, 2010 - Elsevier
The mechanisms by which alloreactive memory T-cells are generated in non-sensitized
individuals have begun to be elucidated. It is generally accepted that a very high level of …
individuals have begun to be elucidated. It is generally accepted that a very high level of …
T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex
T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …
T cell allorecognition via molecular mimicry
T cells often alloreact with foreign human leukocyte antigens (HLA). Here we showed the
LC13 T cell receptor (TCR), selected for recognition on self-HLA-B∗ 0801 bound to a viral …
LC13 T cell receptor (TCR), selected for recognition on self-HLA-B∗ 0801 bound to a viral …
Characteristics and prognostic significance of profiling the peripheral blood T‐cell receptor repertoire in patients with advanced lung cancer
YY Liu, QF Yang, JS Yang, RB Cao… - … journal of cancer, 2019 - Wiley Online Library
Lung cancer is one of the greatest threats to human health, and is initially detected and
attacked by the immune system through tumor‐reactive T cells. The aim of this study was to …
attacked by the immune system through tumor‐reactive T cells. The aim of this study was to …
Generation of MHC class II–peptide ligands for CD4 T-cell allorecognition of MHC class II molecules
Together, these conclusions support the view that allorecognition of MHC class II molecules
is likely to parallel key aspects of conventional CD4 T-cell recognition, with allele-dependent …
is likely to parallel key aspects of conventional CD4 T-cell recognition, with allele-dependent …
A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers
Major histocompatibility complex class I (MHCI) and MHCII proteins differ in structure and
sequence. To understand how T cell receptors (TCRs) can use the same set of variable …
sequence. To understand how T cell receptors (TCRs) can use the same set of variable …
Evolutionarily conserved features contribute to αβ T cell receptor specificity
JP Scott-Browne, F Crawford, MH Young, JW Kappler… - Immunity, 2011 - cell.com
Summary αβ T cell receptors (TCRs) bind specifically to foreign antigens presented by major
histocompatibility complex proteins (MHC) or MHC-like molecules. Accumulating evidence …
histocompatibility complex proteins (MHC) or MHC-like molecules. Accumulating evidence …
Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex
The crystal structures of unliganded and liganded pMHC molecules provide a structural
basis for TCR recognition yet they represent 'snapshots' and offer limited insight into …
basis for TCR recognition yet they represent 'snapshots' and offer limited insight into …
Dynamic changes of T cell receptor repertoires in patients with hepatitis B virus-related acute-on-chronic liver failure
G Shen, S Sun, J Huang, H Deng, Y Xu, Z Wang… - Hepatology …, 2020 - Springer
Background and aims T cell-mediated immune injury plays a critical role in the pathogenesis
of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Given the high short …
of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Given the high short …
Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection
J Juang, PJR Ebert, D Feng, KC Garcia… - Journal of Experimental …, 2010 - rupress.org
T cell selection and maturation in the thymus depends on the interactions between T cell
receptors (TCRs) and different self-peptide–major histocompatibility complex (pMHC) …
receptors (TCRs) and different self-peptide–major histocompatibility complex (pMHC) …