Highlights•Nogo-A limits neural repair and recovery after adult CNS injuries.•NgR1 and
S1PR2 are receptors for different domains of Nogo-A.•Nogo-A and NgR1 limit experience …

Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

A first-ever spinal cord imaging meeting was sponsored by the International Spinal
Research Trust and the Wings for Life Foundation with the aim of identifying the current state …

Background Spinal cord injury (SCI) causes neural disconnection and persistent
neurological deficits, so axon sprouting and plasticity might promote recovery. Soluble Nogo …

Due to irreversible neuronal loss and glial scar deposition, spinal cord injury (SCI) ultimately
results in permanent neurological dysfunction. Neuronal regeneration of neural stem cells …

Axonal damage leads to permanent deficits in the adult central nervous system (CNS) not
only because of the weak intrinsic ability of adult neurons to activate their growth program …

The extracellular environment of the central nervous system (CNS) becomes highly
structured and organized as the nervous system matures. The extracellular space of the …

Adult mammalian central nervous system (CNS) trauma interrupts neural networks and,
because axonal regeneration is minimal, neurological deficits persist. Repair via axonal …

Spinal cord injury (SCI) is a tragic event causing irreversible losses of sensory, motor, and
autonomic functions, that may also be associated with chronic neuropathic pain. Serotonin …

Three theories of regeneration dominate neuroscience today, all purporting to explain why
the adult central nervous system (CNS) cannot regenerate. One theory proposes that Nogo …