Highlights•Drug repositioning and similar terms have been a trending topic since
2004.•From a legal or regulatory perspective stimulation of drug repositioning requires …

A leading innovation scholar explains the growing phenomenon and impact of free
innovation, in which innovations developed by consumers and given away “for free.” In this …

Many available drugs have been repurposed as treatments for neurodevelopmental
disorders. In the specific case of fragile X syndrome, many clinical trials of available drugs …

Exaptation, the emergence of latent functionality in existing artifacts, is an underexplored
mechanism of novelty generation in innovation. In this paper, we measure the frequency of …

Repurposing of medicines has gained a lot of interest from the research community in recent
years as it could offer safe, timely, and affordable new treatment options for cancer patients …

Background Once a drug gets FDA approved, researchers often attempt to discover new
applications in different indications. The clinical impact of such post-approval activities is …

Over the last decade, generic penetration in the US pharmaceutical market has increased
substantially, providing significant gains in consumer surplus. What impact has this rise in …

Commentators claim that drug repositioning (ie developing new uses for authorised drugs)
significantly slows when generics are authorised and, therefore, law reform is necessary to …

Repurposing off-patent drugs has long been proposed as a cost-effective and efficient
strategy to develop new treatments, but its potential has not been realized. Here, we …

Background: Many established products (EPs–marketed for eight years or more) are widely
used off-label despite little evidence on benefit–risk ratio. This exposes patients to risks …