Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

[HTML][HTML] Opportunities of connectomic neuromodulation

A Horn, MD Fox - Neuroimage, 2020 - Elsevier
The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

A somato-cognitive action network alternates with effector regions in motor cortex

EM Gordon, RJ Chauvin, AN Van, A Rajesh, A Nielsen… - Nature, 2023 - nature.com
Motor cortex (M1) has been thought to form a continuous somatotopic homunculus
extending down the precentral gyrus from foot to face representations,, despite evidence for …

Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging

A Horn, N Li, TA Dembek, A Kappel, C Boulay, S Ewert… - Neuroimage, 2019 - Elsevier
Deep brain stimulation (DBS) is a highly efficacious treatment option for movement disorders
and a growing number of other indications are investigated in clinical trials. To ensure …

Connectivity predicts deep brain stimulation outcome in P arkinson disease

A Horn, M Reich, J Vorwerk, N Li, G Wenzel… - Annals of …, 2017 - Wiley Online Library
Objective The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may
depend on connectivity between the stimulation site and other brain regions, but which …

[HTML][HTML] Lead-DBS v3. 0: Mapping deep brain stimulation effects to local anatomy and global networks

C Neudorfer, K Butenko, S Oxenford, N Rajamani… - Neuroimage, 2023 - Elsevier
Following its introduction in 2014 and with support of a broad international community, the
open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform …

A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

N Li, JC Baldermann, A Kibleur, S Treu… - Nature …, 2020 - nature.com
Multiple surgical targets for treating obsessive-compulsive disorder with deep brain
stimulation (DBS) have been proposed. However, different targets may modulate the same …

7 Tesla MRI of the ex vivo human brain at 100 micron resolution

BL Edlow, A Mareyam, A Horn, JR Polimeni, T Witzel… - Scientific data, 2019 - nature.com
We present an ultra-high resolution MRI dataset of an ex vivo human brain specimen. The
brain specimen was donated by a 58-year-old woman who had no history of neurological …

Connectivity profile predictive of effective deep brain stimulation in obsessive-compulsive disorder

JC Baldermann, C Melzer, A Zapf, S Kohl… - Biological …, 2019 - Elsevier
Background Deep brain stimulation for obsessive-compulsive disorder is a rapidly
developing treatment strategy for treatment-refractory patients. Both the exact target and …

Probabilistic sweet spots predict motor outcome for deep brain stimulation in Parkinson disease

TA Dembek, J Roediger, A Horn, P Reker… - Annals of …, 2019 - Wiley Online Library
Objective To investigate whether functional sweet spots of deep brain stimulation (DBS) in
the subthalamic nucleus (STN) can predict motor improvement in Parkinson disease (PD) …