[HTML][HTML] Therapeutic advances of miRNAs: A preclinical and clinical update

C Chakraborty, AR Sharma, G Sharma… - Journal of advanced …, 2021 - Elsevier
Background miRNAs, a class of small endogenous RNAs, are one of the essential
biopharmaceuticals which are in commercial spans as next-generation medicine in recent …

[HTML][HTML] MicroRNA delivery through nanoparticles

SWL Lee, C Paoletti, M Campisi, T Osaki… - Journal of Controlled …, 2019 - Elsevier
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to
their central role in the etiology of major diseases. On the other hand, nanoparticle carriers …

[HTML][HTML] Recent advances in miRNA delivery systems

I Dasgupta, A Chatterjee - Methods and protocols, 2021 - mdpi.com
MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that
are produced in a tissue and time-specific manner to orchestrate gene expression post …

[HTML][HTML] siRNA versus miRNA as therapeutics for gene silencing

JKW Lam, MYT Chow, Y Zhang, SWS Leung - Molecular Therapy-Nucleic …, 2015 - cell.com
Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …

Recent progress in development of siRNA delivery vehicles for cancer therapy

HJ Kim, A Kim, K Miyata, K Kataoka - Advanced drug delivery reviews, 2016 - Elsevier
Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …

[HTML][HTML] Recent progress in microRNA-based delivery systems for the treatment of human disease

Y Fu, J Chen, Z Huang - ExRNA, 2019 - Springer
MicroRNAs (miRNAs) are naturally occurring, small non-coding RNAs that mediate
posttranscriptional regulation. Based on the level of sequence complementarity, miRNAs …

Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model

K Jeong, YJ Yu, JY You, WJ Rhee, JA Kim - Lab on a Chip, 2020 - pubs.rsc.org
Non-small cell lung cancer (NSCLC) is one of the leading causes of death from cancer
worldwide. The delivery and controlled regulation of miRNAs via exosomes is known as a …

[HTML][HTML] Going beyond the liver: progress and challenges of targeted delivery of siRNA therapeutics

C Lorenzer, M Dirin, AM Winkler, V Baumann… - Journal of Controlled …, 2015 - Elsevier
Therapeutic gene silencing promises significant progress in pharmacotherapy, including
considerable expansion of the druggable target space and the possibility for treating orphan …

Extracellular vesicle (ECV)-modified polyethylenimine (PEI) complexes for enhanced siRNA delivery in vitro and in vivo

P Zhupanyn, A Ewe, T Büch, A Malek… - Journal of Controlled …, 2020 - Elsevier
Extracellular vesicles (ECVs) are secreted cell-derived membrane particles involved in
intercellular signaling and cell-cell communication. By transporting various bio …

Innovative approaches in transforming microRNAs into therapeutic tools

AFA Samad, MF Kamaroddin - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an
entire biological pathway by targeting multiple target genes. This characteristic makes …